Publication:
Ameliorating effects of curcumin on 6-OHDA-induced dopaminergic denervation, glial response, and SOD1 reduction in the striatum of hemiparkinsonian mice

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Issued Date

2013

Resource Type

Article

File Type

application/pdf

ISSN

11283602

Other identifier(s)

2-s2.0-84878621998

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

European Review for Medical and Pharmacological Sciences. Vol 17, No.10 (2013), p.1360-1368

Suggested Citation

Tripanichkul W., Jaroensuppaperch E.-O. Ameliorating effects of curcumin on 6-OHDA-induced dopaminergic denervation, glial response, and SOD1 reduction in the striatum of hemiparkinsonian mice. European Review for Medical and Pharmacological Sciences. Vol 17, No.10 (2013), p.1360-1368. Retrieved from: https://hdl.handle.net/20.500.14740/6642

Title

Ameliorating effects of curcumin on 6-OHDA-induced dopaminergic denervation, glial response, and SOD1 reduction in the striatum of hemiparkinsonian mice

Author(s)

Tripanichkul W.
 Jaroensuppaperch E.-O.

Abstract

BACKGROUND: Inflammation and oxidative stress are believed to contribute to neuronal degeneration of the nigrostriatal dopaminergic (DA) pathway in Parkinson's disease. Curcumin, a component of the yellow curry spice, has been reported possessing anti-inflammatory and anti-oxidative effects. AIM: The present study investigated the effects of curcumin on the extent of DA innervation, glial response, and Cu/Zn superoxide dismutase (SOD1) expression in the striatum of 6-hydroxydopamine (6-OHDA)-lesioned mice. MATERIALS AND METHODS: 6-OHDA was unilaterally injected into the right striatum of ICR male mice. Curcumin (200 mg/kg) was administered daily for 7 days starting instantaneously after 6-OHDA injection. Seven days after 6-OHDA insult, mice were euthanized and striatal sections were collected, immunohistochemically stained, and quantitated for tyrosine hydroxylase (TH), glial fibrillary acidic protein (GFAP), ionized calcium binding adapter molecule 1 (Iba1), and SOD1 immunoreactivity. RESULTS: 6-OHDA injection triggered a significant loss of TH-immunoreactive (-IR) axons, induced reaction of GFAP-IR astrocytes and Iba1-IR microglia, and decreased SOD1 expression in the 6-OHDA-lesioned striatum. Curcumin attenuated loss of TH-IR fibers, diminished activation of astrocytes and microglia, and sustained SOD1 level in the lesioned striatum. CONCLUSIONS: These results suggest that curcumin counteracts the neurotoxicity of 6-OHDA through its anti-inflammatory properties (inhibition of glial response) and preservation of SOD1 expression.

Subject(s)

Calcium binding protein
 Calcium binding protein iba1
 Copper zinc superoxide dismutase
 Curcumin
 Glial fibrillary acidic protein
 Oxidopamine
 Tyrosine 3 monooxygenase
 Unclassified drug
 Animal cell
 Animal experiment
 Animal model
 Animal tissue
 Article
 Astrocyte
 Controlled study
 Corpus striatum
 Denervation
 Dopaminergic activity
 Glia
 Immunohistochemistry
 Immunoreactivity
 Male
 Microglia
 Mouse
 Nonhuman
 Parkinsonism
 Protein expression
 Animals
 Anti-Inflammatory Agents
 Corpus Striatum
 Curcumin
 Male
 Mice
 Mice, Inbred ICR
 Neuroglia
 Neuroprotective Agents
 Oxidopamine
 Parkinson Disease
 Superoxide Dismutase
 Tyrosine 3-Monooxygenase

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URI

https://hdl.handle.net/20.500.14740/6642

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Scopus: Year 1983-2021

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