Publication: Antiplasmodial and antimycobacterial cyclopeptide alkaloids from the root of Ziziphus mauritiana
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Issued Date
2011
Resource Type
File Type
application/pdf
ISSN
319422
Other identifier(s)
2-s2.0-79955757528
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Phytochemistry. Vol 72, No.9 (2011), p.909-915
Suggested Citation
Panseeta P., Lomchoey K., Prabpai S., Kongsaeree P., Suksamrarn A., Ruchirawat S., Suksamrarn S. Antiplasmodial and antimycobacterial cyclopeptide alkaloids from the root of Ziziphus mauritiana. Phytochemistry. Vol 72, No.9 (2011), p.909-915. doi:10.1016/j.phytochem.2011.03.003 Retrieved from: https://hdl.handle.net/20.500.14740/7325
Abstract
Investigation of the MeOH extract obtained from the root of the Ziziphus mauritiana grown in Thailand resulted in the isolation of two 14- and 13-membered cyclic alkaloids, mauritine L (1) and mauritine M (2), and three known cyclopeptide alkaloids, nummularines H (3), B (4) and hemsine A (5). Their structures were elucidated on the basis of extensive NMR spectroscopic analysis. The first single crystal X-ray diffraction study of the 13-membered ring cyclopeptide, nummularine B methiodide (4′), revealed all S configurations on the amino acid residues. The isolated alkaloids exhibited potent antiplasmodial activity against the parasite Plasmodium falciparum with the inhibitory concentration (IC50) ranging from 3.7 to 10.3 μM. Compounds 2 and 3 also demonstrated antimycobacterial activity against Mycobacterium tuberculosis with the MIC of 72.8 and 4.5 μM, respectively. © 2011 Elsevier Ltd. All rights reserved.
Subject(s)
Mycobacterium tuberculosis
Plasmodium falciparum
Rhamnaceae
Ziziphus
Ziziphus mauritiana
Alkaloid
Antiinfective agent
Antimalarial agent
Cyclopeptide
Chemical structure
Chemistry
Drug effects
Isolation and purification
Mycobacterium tuberculosis
Plant root
Plasmodium falciparum
Thailand
Ziziphus
Alkaloids
Anti-Bacterial Agents
Antimalarials
Molecular Structure
Mycobacterium tuberculosis
Peptides, Cyclic
Plant Roots
Plasmodium falciparum
Thailand
Ziziphus
Plasmodium falciparum
Rhamnaceae
Ziziphus
Ziziphus mauritiana
Alkaloid
Antiinfective agent
Antimalarial agent
Cyclopeptide
Chemical structure
Chemistry
Drug effects
Isolation and purification
Mycobacterium tuberculosis
Plant root
Plasmodium falciparum
Thailand
Ziziphus
Alkaloids
Anti-Bacterial Agents
Antimalarials
Molecular Structure
Mycobacterium tuberculosis
Peptides, Cyclic
Plant Roots
Plasmodium falciparum
Thailand
Ziziphus