Publication:
Hematologic malignancies associated with mediastinal germ cell tumors: 10 years' experience at Thailand's national pediatric tertiary referral center

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Issued Date

2018

Resource Type

Article

File Type

application/pdf

ISSN

10774114

DOI

10.1097/MPH.0000000000001233

Other identifier(s)

2-s2.0-85048282530

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of Pediatric Hematology/Oncology. Vol 40, No.6 (2018), p.450-455

Suggested Citation

Sowithayasakul P., Sinlapamongkolkul P., Treetipsatit J., Vathana N., Narkbunnam N., Sanpakit K., Buaboonnam J. Hematologic malignancies associated with mediastinal germ cell tumors: 10 years' experience at Thailand's national pediatric tertiary referral center. Journal of Pediatric Hematology/Oncology. Vol 40, No.6 (2018), p.450-455. doi:10.1097/MPH.0000000000001233 Retrieved from: https://hdl.handle.net/20.500.14740/3700

Title

Hematologic malignancies associated with mediastinal germ cell tumors: 10 years' experience at Thailand's national pediatric tertiary referral center

Author(s)

Sowithayasakul P.
 Sinlapamongkolkul P.
 Treetipsatit J.
 Vathana N.
 Narkbunnam N.
 Sanpakit K.
 Buaboonnam J.

Abstract

Mediastinal germ cell tumor (MGCT), which accounts for 1% to 3% of extragonadal germ cell tumors, has unique manifestations; it is associated with several types of hematologic malignancy, particularly myeloid neoplasm. The aim of this study was to report the 10-year incidence, clinical characteristics, and outcomes of MGCT at Thailand's national pediatric tertiary referral center. This retrospective study included patients diagnosed with MGCT at the Department of Pediatrics, Siriraj Hospital during 2005 to 2014. Eight patients (all male) were diagnosed with MGCT. Five of 8 patients were found to have hematologic abnormalities. Three patients were diagnosed with acute myeloid leukemia (AML) (one patient with M1, another having M7, and the other with M0). Another patient had mixed MGCT with mediastinal myeloid sarcoma (MMS). The other patient had malignancy-associated hemophagocytic lymphohistiocytosis syndrome (M-HLH). Isochromosome 12p was detected in 3 patients (AML [2], mixed MGCT/MMS [1]). Four of 5 patients with hematologic abnormalities died of hematologic abnormalities or treatment complication (AML [3], M-HLH [1]). One patient with mixed MGCT/MMS survived with chemotherapy. All patients with AML and MMS were nonseminomatous MGCT and the onset of myeloid malignancies were within 1 year after the diagnosis of MGCT. Associated hematologic malignancies should be suspected in MGCT with abnormal blood count or hematologic symptoms. Isochromosome 12p was the most common cytogenetic finding in MGCT-associated myeloid malignancies patients. Those with nonseminomatous MGCT should have their blood count carefully monitored especially during the first year after the diagnosis of MGCT. Better treatment alternatives for MGCT with associated hematologic malignancies are warranted to ameliorate adverse outcomes. © 2018 Wolters Kluwer Health, Inc. All rights reserved.

Subject(s)

Alpha fetoprotein
 Bleomycin
 Carboplatin
 Chorionic gonadotropin beta subunit
 Cisplatin
 Etoposide
 Ifosfamide
 Lactate dehydrogenase
 Mesna
 Acute myeloid leukemia
 Adolescent
 Article
 Body weight loss
 Bone marrow biopsy
 Cancer incidence
 Cancer survival
 Child
 Chronic cough
 Clinical article
 Clinical feature
 Clinical protocol
 Controlled study
 Correlation analysis
 Cytogenetics
 Disease association
 Disease course
 Fever
 Flow cytometry
 Germ cell tumor
 Granulocytic sarcoma
 Hematologic malignancy
 Hemophagocytic syndrome
 Human
 Human tissue
 Lung function
 Male
 Priority journal
 Protein blood level
 Retrospective study
 School child
 Tertiary care center
 Thailand
 Acute myeloid leukemia
 Granulocytic sarcoma
 Hematologic disease
 Mediastinum tumor
 Mortality
 Neoplasm
 Second cancer
 Adolescent
 Hematologic Neoplasms
 Humans
 Leukemia, Myeloid, Acute
 Male
 Mediastinal Neoplasms
 Neoplasms, Germ Cell and Embryonal
 Neoplasms, Second Primary
 Retrospective Studies
 Sarcoma, Myeloid
 Tertiary Care Centers
 Thailand

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URI

https://hdl.handle.net/20.500.14740/3700

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Scopus: Year 1983-2021

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