Publication:
Hemostatic defects in thai adolescents with menorrhagia

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Issued Date

2010

Resource Type

Article

File Type

application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-77951899258

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 93, No.4 (2010), p.436-442

Suggested Citation

Hutspardol S., Sirachainan N., Soisamrong A., Atchararit N., O-Prasertsawat P., Chuansumrit A. Hemostatic defects in thai adolescents with menorrhagia. Journal of the Medical Association of Thailand. Vol 93, No.4 (2010), p.436-442. Retrieved from: https://hdl.handle.net/20.500.14740/7597

Title

Hemostatic defects in thai adolescents with menorrhagia

Author(s)

Hutspardol S.
 Sirachainan N.
 Soisamrong A.
 Atchararit N.
 O-Prasertsawat P.
 Chuansumrit A.

Abstract

Twenty-eight adolescents with menorrhagia by pictorial blood loss assessment chart (PBAC) criteria were investigated for underlying hemostatic defect. CBC, ABO blood group, bleeding time, APTT, PT, TT, FVIII:C, VWF:Ag, RiCoF and platelet aggregation study were evaluated. Six patients (21.4%) were addressed with underlying hemostatic defect. Of these, severe aplastic anemia (n = 1) and thrombotic thrombocytopenic purpura (n = 1) were identified in 2 patients with low platelets after an initial CBC. Four patients with prolonged bleeding time demonstrated inherited hemostatic defect: von Willebrand disease (VWD) type 3 (n = 1), Glanzmann thrombasthenia (n = 1) and Bernard-Soulier syndrome (n = 2). Median PBAC score of patients with hemostatic defect was significantly higher than that of patients with unknown cause of menorrhagia (436.5 vs. 251.3, p = 0.01). After the exclusion of six patients with well-identified bleeding risks, isolated abnormal platelet aggregation response to adrenaline was detected in 11 (50%) adolescents using platelet aggregation study. No significant difference of median PBAC score was noted among patients with and without evidence of this impaired responsiveness to adrenaline. In addition, the authors also found an abnormal platelet aggregation with adrenaline stimulant in 15 (75%) among 20 healthy female controls who had no history of bleeding diathesis. No significant difference in frequency of abnormal platelet aggregation to adrenaline was observed between affected cases and controls. In summary, an impaired responsiveness of platelets to adrenaline in the present study is insufficient to support its risk of bleeding. On the contrary, the simple test such as CBC and bleeding time revealed a worthy contribution to investigate coexisting coagulopathy in adolescents with menorrhagia.

Subject(s)

Adrenalin
 Antigen
 Blood clotting factor 8
 Von Willebrand factor
 Adolescent
 Adolescent disease
 Aplastic anemia
 Article
 Bernard Soulier disease
 Bleeding tendency
 Bleeding time
 Blood cell count
 Blood clotting disorder
 Blood group ABO system
 Child
 Clinical article
 Clinical evaluation
 Controlled study
 Disease severity
 Female
 Glanzmann disease
 Human
 Menorrhagia
 Partial thromboplastin time
 Prothrombin time
 School child
 Thailand
 Thrombin time
 Thrombocyte aggregation
 Thrombotic thrombocytopenic purpura
 Von Willebrand disease
 Adolescent
 Asian Continental Ancestry Group
 Case-Control Studies
 Child
 Cohort Studies
 Female
 Hemostatic Disorders
 Humans
 Menorrhagia
 Thailand

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URI

https://hdl.handle.net/20.500.14740/7597

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Scopus: Year 1983-2021

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