Publication:
Effects of obstructive sleep apnea on serum brain-derived neurotrophic factor protein, cortisol, and lipid levels

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Issued Date

2011

Resource Type

Article

File Type

application/pdf

ISSN

15209512

DOI

10.1007/s11325-010-0415-7

Other identifier(s)

2-s2.0-84859389181

Rights Holder(s)

Scopus

Bibliographic Citation

Sleep and Breathing. Vol 15, No.4 (2011), p.649-656

Suggested Citation

Panaree B., Chantana M., Wasana S., Chairat N. Effects of obstructive sleep apnea on serum brain-derived neurotrophic factor protein, cortisol, and lipid levels. Sleep and Breathing. Vol 15, No.4 (2011), p.649-656. doi:10.1007/s11325-010-0415-7 Retrieved from: https://hdl.handle.net/20.500.14740/7200

Title

Effects of obstructive sleep apnea on serum brain-derived neurotrophic factor protein, cortisol, and lipid levels

Author(s)

Panaree B.
 Chantana M.
 Wasana S.
 Chairat N.

Abstract

Objectives: Obstructive sleep apnea (OSA) is a sleep-disordered breathing leading to vascular endothelial cells dysfunction, cognitive impairment, and abnormal lipid metabolism. serum brain-derived neurotrophic factor (BDNF) protein, cortisol, and lipid levels in OSA were investigated. Materials and methods: All middle-aged subjects including healthy individuals without signs and symptoms of apneahypopnea and ear nose throat (ENT) outpatients were randomly recruited and screened by overnight polysomnogram (PSG). Apnea-hypopnea index (AHI) was used as a criteria to determine subjects to enroll in this program. According to AHI, they were separated into control and OSA groups. A group of 39 OSA patients (AHI≥10 events/h) and 24 control subjects (AHI<5 events/h) were selected. Serum BDNF protein was analyzed by enzyme-linked immunosorbent assay (ELISA) from venous blood collection at 8:00 a.m. following PSG. Serum cortisol was assayed by enzyme-chemiluminescense immuno assay (ECLIA). Serum lipid profile levels were determined by enzymatic colorimetric and homogeneous method. Results: Characteristics of OSA patients and control groups including gender, age, AHI, body weight, height, and BMI showed significant differences. Serum BDNF protein, cortisol, triglyceride, and total cholesterol levels in OSA and control groups were not significantly different. High density lipoprotein-cholesterol (HDL-c) in OSA was significantly lower than that of control (p=0.008) while low density lipoprotein-cholesterol (LDL-c) was significantly higher than that of control (p=0.04). Conclusions: OSA had no significant effect on serum BDNF, cortisol, triglyceride, or total cholesterol levels while LDL-c and HDL-c levels in OSA patients compared to control were significantly different at p=0.04, and p= 0.008, respectively. © Springer-Verlag 2010.

Subject(s)

Brain derived neurotrophic factor
 Cholesterol
 High density lipoprotein cholesterol
 Hydrocortisone
 Low density lipoprotein cholesterol
 Triacylglycerol
 Brain derived neurotrophic factor
 Hydrocortisone
 Lipid
 Adult
 Age
 Apnea hypopnea index
 Article
 Body height
 Body mass
 Body weight
 Chemoluminescence
 Cholesterol blood level
 Clinical article
 Colorimetry
 Controlled study
 Enzyme linked immunosorbent assay
 Female
 Gender
 Human
 Hydrocortisone blood level
 Male
 Polysomnography
 Priority journal
 Protein blood level
 Sleep apnea syndrome
 Triacylglycerol blood level
 Blood
 Middle aged
 Reference value
 Sleep apnea syndrome
 Thailand
 University hospital
 Academic Medical Centers
 Adult
 Brain-Derived Neurotrophic Factor
 Female
 Humans
 Hydrocortisone
 Lipids
 Male
 Middle Aged
 Polysomnography
 Reference Values
 Sleep Apnea, Obstructive
 Thailand

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URI

https://hdl.handle.net/20.500.14740/7200

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Scopus: Year 1983-2021

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