Publication: ADIPOQ polymorphisms among Thais with pre-diabetes
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0
Issued Date
2016
Resource Type
File Type
application/pdf
ISSN
1251562
Other identifier(s)
2-s2.0-85024488451
Rights Holder(s)
Scopus
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol 47, No.6 (2016), p.1306-1314
Suggested Citation
Chaikhiandee S., Phonrat B., Tungtrongchitr A., Suriyaprom K., Chuengsamarn S., Uttamachai C., Tungtrongchitr R. ADIPOQ polymorphisms among Thais with pre-diabetes. Southeast Asian Journal of Tropical Medicine and Public Health. Vol 47, No.6 (2016), p.1306-1314. Retrieved from: https://hdl.handle.net/20.500.14740/5973
Abstract
Studies have shown that polymorphisms of adiponectin gene (ADIPOQ) are associated with risk of developing type 2 diabetes mellitus (T2DM). However, no studies have investigated the association between genetic variants of ADIPOQ and pre-diabetes, a group at higher risk for developing T2DM. A total of 75 pre-diabetes and 130 normal subjects were recruited from volunteers in Bangkok, Thailand. Individuals with pre-diabetes were selected based on American Diabetes Association diagnostic criteria. Six ADIPOQ polymorphisms were genotyped using polymerase chain reaction-restriction fragment length polymorphism technique. ADIPOQ polymorphism rs266729 C>G is significantly associated with pre-diabetes (p = 0.006). CG/GG genotypes were found among 60% and 40% of pre-diabetes and normal subjects, respectively. SNP rs266729 C>G was associated with increased pre-diabetes risk (OR = 2.64; 95% CI: 1.18-5.89, p = 0.018). No significant differences were found between pre-diabetes and normal subjects for other ADIPOQ polymorphisms. However, haplotype analysis revealed that haplotype GGTAAT is significantly associated with pre-diabetes when compared with GCGAAC reference haplotype (OR = 22.31; 95% CI: 1.37-361.93, p = 0.03). Our data indicate that ADIPOQ rs266729 C>G polymorphism may contribute to the genetic risk of pre-diabetes and provide preliminary data useful in genetic screening for pre-diabetes among Thais. © 2017, SEAMEO TROPMED Network. All Rights Reserved.
Subject(s)
Adiponectin
ADIPOQ protein, human
Adult
Case control study
Female
Genetic polymorphism
Genetic predisposition
Genetics
Genotype
Human
Impaired glucose tolerance
Male
Middle aged
Retrospective study
Thailand
Adiponectin
Adult
Case-Control Studies
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Polymorphism, Genetic
Prediabetic State
Retrospective Studies
Thailand
ADIPOQ protein, human
Adult
Case control study
Female
Genetic polymorphism
Genetic predisposition
Genetics
Genotype
Human
Impaired glucose tolerance
Male
Middle aged
Retrospective study
Thailand
Adiponectin
Adult
Case-Control Studies
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Polymorphism, Genetic
Prediabetic State
Retrospective Studies
Thailand