Publication: Effects of Curcurma cotnosa Roxb. On platelet aggregation and atherosclerotic plaque development in hypercholesterolemic rabbits
0
0
Issued Date
2012
Resource Type
File Type
application/pdf
ISSN
18117775
Other identifier(s)
2-s2.0-84859074698
Rights Holder(s)
Scopus
Bibliographic Citation
International Journal of Pharmacology. Vol 8, No.4 (2012), p.234-242
Suggested Citation
Ratanachamnong P., Matsathit U., Sanvarinda Y., Piyachaturawat P., Phivthong-Ngam L. Effects of Curcurma cotnosa Roxb. On platelet aggregation and atherosclerotic plaque development in hypercholesterolemic rabbits. International Journal of Pharmacology. Vol 8, No.4 (2012), p.234-242. doi:10.3923/ijp.2012.234.242 Retrieved from: https://hdl.handle.net/20.500.14740/7081
Abstract
Curcuma comosa Roxb. (C. comosa), an indigenous medicinal plant containing phytoestrogens, has been reported to have hypocholesterolemic and anti-inflammatory effects. Hypercholesterolemia and inflammation play crucial roles in the development of atherosclerosis. In the present study we investigated whether the hexane extract of C. comosa inhibits atherosclerotic plaque formation and platelet aggregation in hypercholesterolemic rabbits. Rabbits were fed 0.5% cholesterol (N = 6), 0.5% cholesterol plus 5 mg day -1 of simvastatin (N = 6), 0.5% cholesterol plus 100 mg kg -1 b.wt/day of C. Comosa extract (N = 6) or normal rabbit chow (N = 6) for 12 weeks. Blood samples for cholesterol determination were collected in monthly intervals. At the end of the study period, platelet aggregation ex vivo, endothelium-dependent and -independent vascular function of isolated aortic rings ex vivo and aortic plaques were assessed. Cholesterol feeding to the rabbits for 12 weeks significantly increased plasma lipid profiles, platelet aggregation and impaired endothelium-dependent relaxations to ACh and ADP. Supplement with simvastatin or hexane extract of C. comosa attenuated platelet aggregation, plasma lipid profiles and partly restored endothelium-mediated vascular responses. Both simvastatin and hexane extract of C. comosa also improved aortic intimal thickening by about 76 and 74%, respectively. The results indicate that hexane extract of C. comosa possesses the beneficial effects in hypercholesterolemia in similar manner to simvastatin. The therapeutic potential for the prevention or regression of atherosclerosis should be further investigated. © 2012 Asian Network for Scientific Information.
Subject(s)
Acetylcholine
Adenosine diphosphate
Cholesterol
Curcuma comosa extract
Hypocholesterolemic agent
Lipid
Nitroprusside sodium
Plant extract
Simvastatin
Unclassified drug
Animal cell
Animal experiment
Animal model
Animal tissue
Aorta
Aorta atherosclerosis
Artery intima proliferation
Article
Atherosclerotic plaque
Cholesterol blood level
Controlled study
Curcuma
Curcuma comosa
Ex vivo study
Hypercholesterolemia
Lipid blood level
Male
Nonhuman
Thrombocyte aggregation
Vascular endothelium
Vasodilatation
Adenosine diphosphate
Cholesterol
Curcuma comosa extract
Hypocholesterolemic agent
Lipid
Nitroprusside sodium
Plant extract
Simvastatin
Unclassified drug
Animal cell
Animal experiment
Animal model
Animal tissue
Aorta
Aorta atherosclerosis
Artery intima proliferation
Article
Atherosclerotic plaque
Cholesterol blood level
Controlled study
Curcuma
Curcuma comosa
Ex vivo study
Hypercholesterolemia
Lipid blood level
Male
Nonhuman
Thrombocyte aggregation
Vascular endothelium
Vasodilatation