Publication:
Microtextured surfaces for deep-brain stimulation electrodes: A biologically inspired design to reduce lead migration

0
0

Issued Date

2012

Resource Type

Review

File Type

application/pdf

ISSN

18788750

DOI

10.1016/j.wneu.2011.06.040

Other identifier(s)

2-s2.0-84863410107

Rights Holder(s)

Scopus

Bibliographic Citation

World Neurosurgery. Vol 77, No.44289 (2012), p.569-576

Suggested Citation

Parittotokkaporn T., Thomas D.G.T., Schneider A., Huq E., Davies B.L., Degenaar P., Rodriguez Y Baena F. Microtextured surfaces for deep-brain stimulation electrodes: A biologically inspired design to reduce lead migration. World Neurosurgery. Vol 77, No.44289 (2012), p.569-576. doi:10.1016/j.wneu.2011.06.040 Retrieved from: https://hdl.handle.net/20.500.14740/7102

Title

Microtextured surfaces for deep-brain stimulation electrodes: A biologically inspired design to reduce lead migration

Author(s)

Parittotokkaporn T.
 Thomas D.G.T.
 Schneider A.
 Huq E.
 Davies B.L.
 Degenaar P.
 Rodriguez Y Baena F.

Abstract

Objective: Hardware-related complications of deep brain stimulation (DBS) surgery have been reported with adverse effects in postoperative electrode migration. We report that the addition of microtextured features to the surface of a DBS-like probe can minimize the extent of electrode migration in ex vivo porcine brain. Methods: A DBS lead and microtextured strips, mounted with a fiberoptic displacement sensor, were embedded 15-mm deep inside a cadaveric porcine brain through holes on the skull. The local displacement of brain tissue surrounding each strip was detected along the direction of insertion by the optical sensor while the porcine head simulated brain shift during rotation between supine and upright postures. Results: The triangular toothed strip with protruding height of 250 μm enabled a better grip of the surrounding brain tissue than standard DBS lead, minimizing local brain displacement to 77 μm versus 326 μm respectively, when the porcine head was shifted from the supine to the upright position as the result of gravity. In addition, brain tissue damage resulting from the removal of toothed strips exhibited less-extensive tissue disruption, attributable to the microtextured surface. Conclusions: These preliminary results show that microtextured strips embedded into cadaveric porcine brain produce an anchoring effect on local tissue during brain shift, suggesting a way to reduce DBS lead migration without additional tissue damage beyond the strip geometry. © 2012 Elsevier Inc. All rights reserved.

Subject(s)

Lead
 Animal tissue
 Biosensor
 Body position
 Brain depth stimulation
 Brain tissue
 Cadaver
 Electrode
 Ex vivo study
 Fiber optics
 Gravity
 Medical instrumentation
 Migration
 Nonhuman
 Review
 Skull
 Supine position
 Swine
 Tissue injury
 Algorithms
 Animals
 Brain
 Cadaver
 Deep Brain Stimulation
 Device Removal
 Electrodes, Implanted
 Equipment Design
 External Fixators
 Foreign-Body Migration
 Friction
 Posture
 Swine

View online Resources

Research Projects

Organizational Units

Journal Issue

URI

https://hdl.handle.net/20.500.14740/7102

Collections

Scopus: Year 1983-2021

Endorsement

Review

Supplemented By

Referenced By