Publication: Molecular analysis of haemoglobin E in Southeast Asian populations
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Issued Date
2017
Resource Type
File Type
application/pdf
ISSN
3014460
Other identifier(s)
2-s2.0-85031780244
Rights Holder(s)
Scopus
Bibliographic Citation
Annals of Human Biology. Vol 44, No.8 (2017), p.747-750
Suggested Citation
Jomoui W., Fucharoen G., Sanchaisuriya K., Nguyen N.T., Nguyen H.V., Fucharoen S. Molecular analysis of haemoglobin E in Southeast Asian populations. Annals of Human Biology. Vol 44, No.8 (2017), p.747-750. doi:10.1080/03014460.2017.1388844 Retrieved from: https://hdl.handle.net/20.500.14740/4007
Abstract
Haemoglobin (Hb) E is the most common Hb variant in Asia where its gene frequency approaches 0.3 in some areas. We studied genetic background of Hb E genes among Southeast Asian populations. This study examined β-globin gene haplotypes linked to haemoglobin E (Hb E) in diverse groups of Southeast Asian populations. The study was conducted on southern Thai (22 alleles), Cambodian (84 alleles), Laotian (120 alleles), Vietnamese (87 alleles) and Burmese (one allele) subjects. Results were compared with those of previous studies in northeast Thailand, the Yunnan of China, West India and Europe. Ten different haplotypes were observed. The four most common haplotypes were haplotypes 1 (– +–+ + + –) and 2 (+–––– + –) on chromosomes with framework 2 and haplotypes 6 (– +–+ +–+) and 7 (+–––––+) on chromosomes with framework 3 variety. Phylogenetic analysis indicated that haplotype 1 is a relatively recent haplotype found in all populations, whereas haplotype 6 is found predominately in Cambodians. The results indicate that at least two genetic origins of Hb E are responsible for the high prevalence and spread of Hb E among Southeast Asian populations. © 2017 Informa UK Limited, trading as Taylor & Francis Group.