Publication:
Close monitoring of eGFR should be performed in HIV-infected patients aged over 37 years

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Issued Date

2017

Resource Type

Article

File Type

application/pdf

ISSN

13446304

DOI

10.7883/yoken.JJID.2016.370

Other identifier(s)

2-s2.0-85035146945

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Japanese Journal of Infectious Diseases. Vol 70, No.6 (2017), p.656-659

Suggested Citation

Limkunakul C., Srinithiwat P., Lochinda B., Sawanyawisuth K. Close monitoring of eGFR should be performed in HIV-infected patients aged over 37 years. Japanese Journal of Infectious Diseases. Vol 70, No.6 (2017), p.656-659. doi:10.7883/yoken.JJID.2016.370 Retrieved from: https://hdl.handle.net/20.500.14740/4603

Title

Close monitoring of eGFR should be performed in HIV-infected patients aged over 37 years

Author(s)

Limkunakul C.
 Srinithiwat P.
 Lochinda B.
 Sawanyawisuth K.

Abstract

Chronic kidney disease (CKD) has been shown to be a poor prognostic factor in HIV patients. This study aimed to identify risk factors in HIV-infected patients with early decline in renal function or an estimated glomerular filtration rate (eGFR) less than 90 mL/min/1.73 m2. The study was retrospectively conducted at Panyananthaphikkhu Chonprathan Medical Center, Thailand. The inclusion criteria were HIV-infected adult patients who were treated at the hospital’s HIV clinic and whose eGFR levels at the first visit had been evaluated. Eligible patients were categorized according to their eGFR level being lesser or greater than 90 mL/min/1.73 m2. Multivariate logistic analysis was performed to evaluate the association of risk factors with an eGFR of less than 90 mL/min/1.73 m2. There were 301 HIV-infected patients included in the study. Of those, 89 patients (29.57%) had an eGFR of less than 90 mL/min/1.73 m2. Age was the only significant risk factor associated with an eGFR of less than 90 mL/ min/1.73 m2 with an adjusted odds ratio of 1.072 (95% confidence interval: 1.015–1.132). Age of over 37 years predicted an eGFR of less than 90 mL/min/1.73 m2 as a risk factor in HIV-infected patients, with a sensitivity of 80.9% and specificity of 34.91%. Age was independently associated with eGFRs of less than 90 mL/min/1.73 m2 in HIV-infected patients. Close monitoring of eGFR should be performed in HIV-infected patients aged over 37 years. © 2017, National Institute of Health. All rights reserved.

Subject(s)

Atazanavir
 Didanosine
 Efavirenz
 Indinavir
 Lamivudine
 Lopinavir plus ritonavir
 Nevirapine
 Stavudine
 Tenofovir
 Tenofovir disoproxil
 Zidovudine
 Anti human immunodeficiency virus agent
 Biological marker
 Adult
 Article
 Body mass
 Clinical feature
 Coronary artery disease
 Creatinine blood level
 Cryptococcosis
 Diabetes mellitus
 Disease course
 Disease transmission
 Environmental monitoring
 Estimated glomerular filtration rate
 Female
 Genetic association
 Human
 Human immunodeficiency virus infection
 Hypertension
 Major clinical study
 Male
 Middle aged
 Mortality
 Multivariate analysis
 Outcome assessment
 Receiver operating characteristic
 Retrospective study
 Risk factor
 Sensitivity and specificity
 Age
 Chronic kidney failure
 Comorbidity
 Complication
 Glomerulus filtration rate
 Highly active antiretroviral therapy
 Human immunodeficiency virus infection
 Mixed infection
 Prognosis
 Thailand
 Virology
 Adult
 Age Factors
 Anti-HIV Agents
 Antiretroviral Therapy, Highly Active
 Biomarkers
 Coinfection
 Comorbidity
 Female
 Glomerular Filtration Rate
 HIV Infections
 Humans
 Male
 Middle Aged
 Prognosis
 Renal Insufficiency, Chronic
 Retrospective Studies
 ROC Curve
 Thailand

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URI

https://hdl.handle.net/20.500.14740/4603

Collections

Scopus: Year 1983-2021

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