Publication:
Plasticizing effect of ibuprofen induced an alteration of drug released from Kollidon SR matrices produced by direct compression

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Issued Date

2015

Resource Type

Article

File Type

application/pdf

ISSN

3639045

DOI

10.3109/03639045.2014.925917

Other identifier(s)

2-s2.0-84930509716

Rights Holder(s)

Scopus

Bibliographic Citation

Drug Development and Industrial Pharmacy. Vol 41, No.6 (2015), p.1037-1046

Suggested Citation

Wiranidchapong C., Ruangpayungsak N., Suwattanasuk P., Shuwisitkul D., Tanvichien S. Plasticizing effect of ibuprofen induced an alteration of drug released from Kollidon SR matrices produced by direct compression. Drug Development and Industrial Pharmacy. Vol 41, No.6 (2015), p.1037-1046. doi:10.3109/03639045.2014.925917 Retrieved from: https://hdl.handle.net/20.500.14740/6135

Title

Plasticizing effect of ibuprofen induced an alteration of drug released from Kollidon SR matrices produced by direct compression

Author(s)

Wiranidchapong C.
 Ruangpayungsak N.
 Suwattanasuk P.
 Shuwisitkul D.
 Tanvichien S.

Abstract

The objectives of this study were to investigate the effect of storage temperature on drug release from matrices containing 10, 40 and 70% w/w ibuprofen in Kollidon® SR (KSR). The matrix tablets were produced by direct compression and then kept at 30 and 45 °C for 3 months. Drug release from the matrix tablets was examined after storage for 0, 1, 4 and 12 weeks. Scanning electron microscope was used to reveal physical appearance of the tablet surface at the respective time intervals. In addition, differential scanning calorimeter was used to investigate glass transition temperature (Tg) of ibuprofen in KSR at 0-100% w/w based on the principle of Gordon-Taylor equation. At 45 °C, the dissolution of ibuprofen in KSR as well as the coalescence of polymer particles were observed to be higher than those of storage at 30 °C. The physical state of ibuprofen dispersed in the polymeric matrix and degree of polymer coalescence led to the variation of drug release. The coalescence of polymer particles was a result of the polymer transition from glassy to rubbery state according to water absorption of KSR and plasticizing effect of ibuprofen. The reduction of the Tg of ibuprofen blended with KSR could be better described by the Kwei equation, a modified version of Gordon-Taylor equation. © 2014 Informa Healthcare USA, Inc.

Subject(s)

Ibuprofen
 Polymer
 Povidone
 Drug carrier
 Ibuprofen
 Plasticizer
 Povidone
 Tablet
 Article
 Calorimeter
 Drug release
 Drug solubility
 Glass transition temperature
 Infrared spectroscopy
 Mathematical analysis
 Scanning electron microscope
 Scanning electron microscopy
 Storage temperature
 Tablet compression
 Tablet matrix
 Tablet surface
 Water absorption
 Chemistry
 Differential scanning calorimetry
 Drug formulation
 Drug release
 Drug storage
 Medicinal chemistry
 Pressure
 Procedures
 Tablet
 Temperature
 Transition temperature
 Calorimetry, Differential Scanning
 Chemistry, Pharmaceutical
 Drug Carriers
 Drug Compounding
 Drug Liberation
 Drug Storage
 Ibuprofen
 Microscopy, Electron, Scanning
 Plasticizers
 Povidone
 Pressure
 Tablets
 Temperature
 Transition Temperature

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URI

https://hdl.handle.net/20.500.14740/6135

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Scopus: Year 1983-2021

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