Publication: The impact of the toll-like receptor 1 (TLR1) variation rs5743557 on tuberculosis susceptibility in the Thai population
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Issued Date
2025-09-30
Resource Type
ISSN
20721439
eISSN
20776624
Scopus ID
2-s2.0-105017878556
Journal Title
Journal of Thoracic Disease
Volume
17
Issue
9
Start Page
6560
End Page
6568
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Thoracic Disease Vol.17 No.9 (2025) , 6560-6568
Suggested Citation
Saengchart C., Nimitsurachat N., Phaisal W., Kawkitinarong K., Chariyavilaskul P., Chamnanphon M., Ubolyam S., Jaisin Y., Samatiwat P., Rattanacheeworn P. The impact of the toll-like receptor 1 (TLR1) variation rs5743557 on tuberculosis susceptibility in the Thai population. Journal of Thoracic Disease Vol.17 No.9 (2025) , 6560-6568. 6568. doi:10.21037/jtd-2025-147 Retrieved from: https://hdl.handle.net/20.500.14740/50601
Corresponding Author(s)
Other Contributor(s)
Abstract
Background: Tuberculosis (TB) remains a major public health concern in Thailand and worldwide. Genetic factors, including single nucleotide polymorphisms (SNPs), play a part in influencing susceptibility to TB. The aim of this study was to investigate the allele and genotype frequencies of the rs5743557 (G>A) polymorphism and its potential impact on TB susceptibility in the Thai population. Methods: A total of 149 leftover peripheral blood mononuclear cell (PBMC) samples were collected and divided into two groups: patients with TB (TB group, n=92) and patients without TB (non-TB group, n=57). TaqMan real-time polymerase chain reaction (PCR) was performed for genotyping. Logistic regression analysis was performed to assess the association between rs5743557 (G>A) and susceptibility to TB. Results: The analysis revealed that the A allele of the rs5743557 variant was relatively prevalent in the study population. Although a trend indicated that individuals carrying the A allele may have a reduced probability of developing TB, the association did not reach statistical significance. Conclusions: Our findings reveal a trend of reduced TB susceptibility in rs5743557 allele A, although it did not reach statistical significance. There is clinical relevance, marking a promising starting point for further research within the Thai population. In addition, this perspective opens avenues for future research efforts in the field.