Publication:
The Predictive role of Neutrophil-to-Lymphocyte Ratio (NLR) and Mean Platelet Volume-to-Lymphocyte Ratio (MPVLR) for Cardiovascular Events in Adult Patients with Acute Heart Failure

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Issued Date

2021

Resource Type

Article

Language

eng

File Type

application/pdf

ISSN

9629351

DOI

10.1155/2021/6889733

Other identifier(s)

2-s2.0-85118200844

Rights Holder(s)

Scopus

Bibliographic Citation

Mediators of Inflammation. Vol 2021, No. (2021)

Suggested Citation

Angkananard T., Inthanoo T., Sricholwattana S., Rattanajaruskul N., Wongsoasu A., Roongsangmanoon W. The Predictive role of Neutrophil-to-Lymphocyte Ratio (NLR) and Mean Platelet Volume-to-Lymphocyte Ratio (MPVLR) for Cardiovascular Events in Adult Patients with Acute Heart Failure. Mediators of Inflammation. Vol 2021, No. (2021). doi:10.1155/2021/6889733 Retrieved from: https://hdl.handle.net/20.500.14740/7964

Title

The Predictive role of Neutrophil-to-Lymphocyte Ratio (NLR) and Mean Platelet Volume-to-Lymphocyte Ratio (MPVLR) for Cardiovascular Events in Adult Patients with Acute Heart Failure

Author(s)

Angkananard T.
 Inthanoo T.
 Sricholwattana S.
 Rattanajaruskul N.
 Wongsoasu A.
 Roongsangmanoon W.

Abstract

Introduction. The inflammatory response plays a potential role for the pathogenesis and adverse outcomes of heart failure (HF). We aimed to explore the predictive role of baseline neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume-to-lymphocyte ratio (MPVLR) on cardiovascular events (CVEs) in patients hospitalized with acute HF. Materials and Methods. A retrospective cohort study was conducted in 321 patients with HF between January 2017 and December 2019. The association between their NLR, MPVLR, and combined NLR and MPVLR and CVEs, rehospitalization for HF, in-hospital death, and a composite outcome was explored by survival analysis using a Cox proportional hazard model. They were separately investigated and compared with the area under the receiver operating characteristics curve (AUC). Results. Up to the end of the 3-year follow-up, 96 (29.9%) had CVEs, 106 (33.0%) died, 62 (19.3%) were rehospitalized with HF, and 21 (6.5%) died during admission. The NLR and MPVLR were significantly associated with CVEs (adjusted HR for NLR≥3.29, 3.11; 95% CI, 1.98-4.89; MPVLR≥8.57, 2.86; 95% CI, 1.87-4.39), readmissions for HF (adjusted HR for NLR≥3.58, 2.70; 95% CI, 1.58-4.61; MPVLR≥6.43, 2.84; 95% CI,1.59-5.07), in-hospital mortality (adjusted HR for NLR≥3.29, 9.54; 95% CI, 2.19-41.40; MPVLR≥8.57, 7.87; 95% CI, 2.56-24.19), and composite outcome (adjusted HR for NLR≥3.32, 4.76; 95% CI, 3.29-6.89; MPVLR≥7.07, 3.64; 95% CI, 2.58-5.15). The AUC of NLR and MPVLR for CVEs were 0.67 (95% CI, 0.61-0.72) and 0.63 (95% CI, 0.58-0.69). Combined NLR and MPVLR increased the AUC to 0.77 (95% CI, 0.72-0.83) with statistical significance. Conclusion. The elevated NLR and MPVLR on admission in patients with acute HF were independently associated with worse CVEs, rehospitalization for HF, in-hospital death, and composite outcomes. These economical biomarkers should be considered in the management and follow-up care of patients with acute HF. © 2021 Teeranan Angkananard et al.

Subject(s)

Acetylsalicylic acid
 Beta adrenergic receptor blocking agent
 Dipeptidyl carboxypeptidase inhibitor
 Diuretic agent
 Hydroxymethylglutaryl coenzyme A reductase inhibitor
 Purinergic P2Y receptor antagonist
 Troponin
 Absolute lymphocyte count
 Acute heart failure
 Aged
 Article
 Blood cell ratio
 Body mass
 Cohort analysis
 Controlled study
 Diabetes mellitus
 Dyslipidemia
 Electronic medical record
 Female
 Follow up
 Heart left ventricle ejection fraction
 Hospital readmission
 Hospitalization
 Human
 Hypertension
 In-hospital mortality
 Major clinical study
 Male
 Mean platelet volume to lymphocyte ratio
 Neutrophil lymphocyte ratio
 New York Heart Association class
 Predictive value
 Pulse rate
 Retrospective study
 Sensitivity and specificity
 Survival analysis
 Transthoracic echocardiography

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URI

https://hdl.handle.net/20.500.14740/7964

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Scopus: Year 1983-2021

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