Publication: Anti-inflammatory and cytotoxic agents from Xylaria sp. SWUF09-62 fungus
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Issued Date
2019
Resource Type
File Type
application/pdf
ISSN
14786419
Other identifier(s)
2-s2.0-85071024282
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Natural Product Research. (2019)
Suggested Citation
Patjana T., Jantaharn P., Katrun P., Mongkolthanaruk W., Suwannasai N., Senawong T., Tontapha S., Amornkitbumrung V., Mccloskey S. Anti-inflammatory and cytotoxic agents from Xylaria sp. SWUF09-62 fungus. Natural Product Research. (2019). doi:10.1080/14786419.2019.1652292 Retrieved from: https://hdl.handle.net/20.500.14740/5677
Abstract
The ongoing search for anti-cancer agents from microorganisms led to the isolation of four new compounds including 6-ethyl-8-hydroxy-4H-chromen-4-one (1), 6-ethyl-7,8-dihydroxy-4H-chromen-4-one (2), (3S)-3,4-dihydro-8-hydroxy-7-methoxy-3-methylisocoumarin (3) and (3S)-3,4-dihydro-5,7,8-trihydroxy-3-methylisocoumarin (4), together with eleven known compounds (5–15) from Xylaria sp. SWUF09-62 fungus. The chemical structures were deduced from IR, 1D and 2D NMR, and MS data. The absolute configurations of 3 and 4 were determined by ECD experiment. Compounds 2 and 4 indicated possible chemo-prevention and chemo-therapeutic properties, exhibited anti-inflammatory properties by reducing nitric oxide production in LPS-stimulated RAW264.7 cells (IC50 = 1.57 ± 0.25 and 3.02 ± 0.27 μg/mL) and cytotoxicity against HT29 cells (IC50 = 16.46 ± 0.48 and 97.78 ± 7.14 μg/mL). © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.