Publication:
A comparison of mean platelet volume between viral hepatitis and non-viral hepatitis in liver cirrhosis

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Issued Date

2021

Resource Type

Article

Language

eng

File Type

application/pdf

ISSN

1252208

DOI

10.35755/jmedassocthai.2021.S03.00005

Other identifier(s)

2-s2.0-85116017331

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 104, No.9 (2021), p.S1-S8

Suggested Citation

Reinthong R., Makruasi S., Chonmaitree P., Makruasi N. A comparison of mean platelet volume between viral hepatitis and non-viral hepatitis in liver cirrhosis. Journal of the Medical Association of Thailand. Vol 104, No.9 (2021), p.S1-S8. doi:10.35755/jmedassocthai.2021.S03.00005 Retrieved from: https://hdl.handle.net/20.500.14740/3865

Title

A comparison of mean platelet volume between viral hepatitis and non-viral hepatitis in liver cirrhosis

Author(s)

Reinthong R.
 Makruasi S.
 Chonmaitree P.
 Makruasi N.

Abstract

Background: A high level of mean platelet volume (MPV) is associated with platelet activation, which occurs in chronic inflammatory disease. Several studies have demonstrated that a high MPV is associated with chronic viral hepatitis and hepatic fibrosis. However, the role of MPV in patients with cirrhosis is unclear. Objectives: To evaluate the MPV in patients with cirrhosis, and to compare the MPV between viral hepatitis and non-viral hepatitis groups. Moreover, the correlation of MPV and factors was also explored. Materials and Methods: The medical records of 420 cirrhosis outpatients from 2010 to 2017 at Her Royal Highness (HRH) Princess Maha Chakri Sirindhorn Medical center were reviewed and analyzed as a retrospective study. The MPV was expressed as mean±SD. The correlation between MPV values and cirrhosis parameters including mortality outcomes were evaluated. Results: According to retrospective data, the mean age was 56.23 (SD 12.77). Two-hundred and ninety-two patients were males (69.5%), and one-hundred and twenty-eight patients were females (30.5%). Child-Pugh scores A, B, and C were found in 286 (68.1%), 132 (31.4%), and 2 (0.5%) cases, respectively. There was a significant difference of MPV between the group of viral hepatitis and non-viral hepatitis cirrhosis (10.79±1.05 vs. 10.54±1.00; 95% CI, 0.06 to 0.45), respectively. The median time of follow-up in this study was 40.06 months (range, 0.07 to 121.41). The mortality rate was 18.3%. Elevated MPV was found inversely correlated with albumin and platelet counts, and positive correlation with levels of prothrombin time, and INR in all causes of cirrhosis especially chronic viral hepatitis. However, there was no correlation of MPV and long-term mortality outcomes in all causes of cirrhosis (r=-0.066, 95% CI -0.165 to 0.035) and viral hepatitis causes (r=-0.035, 95% CI -0.158 to 0.095). Conclusion: The difference of MPV between viral hepatitis and non-viral hepatitis groups causing liver cirrhosis was identified in our study. The MPV was not correlated with long-term mortality outcomes in cirrhotic patients. © JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND.

Subject(s)

Albumin
 Creatinine
 Adult
 Alcohol consumption
 Article
 Autoimmune hepatitis
 Blood cell count
 Cholestasis
 Chronic kidney failure
 Chronic viral hepatitis
 Diabetes mellitus
 Dyslipidemia
 Echography
 Female
 Glomerulus filtration rate
 Gout
 Heart disease
 Hematocrit
 Hepatitis B
 Hepatitis C
 Human
 Human experiment
 Leukocyte count
 Liver cirrhosis
 Male
 Mean corpuscular volume
 Mean platelet volume
 Middle aged
 Monocyte count
 Neutrophil count
 Neutrophil lymphocyte ratio
 Prothrombin time
 Retrospective study
 Steatohepatitis
 Virus hepatitis

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URI

https://hdl.handle.net/20.500.14740/3865

Collections

Scopus: Year 1983-2021

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