Publication: The Development of Blue Light Activated Methacrylated Hyaluronic Acid Hydrogel for Drug Delivery System
3
0
Issued Date
2023-01-01
Resource Type
ISSN
19054637
eISSN
30277922
Scopus ID
2-s2.0-85202547994
Journal Title
Thai Journal of Pharmaceutical Sciences
Volume
47
Issue
4
Rights Holder(s)
SCOPUS
Bibliographic Citation
Thai Journal of Pharmaceutical Sciences Vol.47 No.4 (2023)
Suggested Citation
Chaopanitcharoen P., Dhanesuan N., Luckanagul J.A., Rungsiyanont S. The Development of Blue Light Activated Methacrylated Hyaluronic Acid Hydrogel for Drug Delivery System. Thai Journal of Pharmaceutical Sciences Vol.47 No.4 (2023). doi:10.56808/3027-7922.2839 Retrieved from: https://hdl.handle.net/20.500.14740/20129
Author's Affiliation
Corresponding Author(s)
Other Contributor(s)
Abstract
Objective: The aim of this study was to develop blue light-activated methacrylated hyaluronic acid (MeHA) hydrogel for further used as biomaterials-delivering system in the tissue engineering field. Materials and Methods: The MeHA hydrogel was synthesized with various concentrations of lithium phenyl-2,4,6-trimethylbenzoyl phosphonate (LAP) added as a photoinitiator. The hydrogel was then exposed to several durations of 480 nm blue light to promote proper crosslinking. Physical properties including surface morphology under scanning electron microscopy (SEM), gelation time, swelling properties, and protein-releasing profiles were determined. Results: It was found that LAP at 15 mg/L per 100 mg/L of MeHA with 90 s of blue light activated showed the best gel formation with proper physical properties and morphology. Conclusion: The blue light-activated MeHA hydrogel with appropriate physical properties was developed. This product is for further clinical study.