Publication:
Comparison of Endothelial Keratoplasty Techniques in Patients With Prior Glaucoma Surgery: A Case-Matched Study

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Issued Date

2019

Resource Type

Article

File Type

application/pdf

ISSN

29394

DOI

10.1016/j.ajo.2019.03.020

Other identifier(s)

2-s2.0-85068884475

Rights Holder(s)

Scopus

Bibliographic Citation

American Journal of Ophthalmology. Vol 206, (2019), p.94-101

Suggested Citation

Lin S.R., Prapaipanich P., Yu F., Law S.K., Caprioli J., Aldave A.J., Deng S.X. Comparison of Endothelial Keratoplasty Techniques in Patients With Prior Glaucoma Surgery: A Case-Matched Study. American Journal of Ophthalmology. Vol 206, (2019), p.94-101. doi:10.1016/j.ajo.2019.03.020 Retrieved from: https://hdl.handle.net/20.500.14740/5140

Title

Comparison of Endothelial Keratoplasty Techniques in Patients With Prior Glaucoma Surgery: A Case-Matched Study

Author(s)

Lin S.R.
 Prapaipanich P.
 Yu F.
 Law S.K.
 Caprioli J.
 Aldave A.J.
 Deng S.X.

Abstract

Purpose: To compare the outcomes of Descemet membrane endothelial keratoplasty (DMEK) with those of Descemet's stripping endothelial keratoplasty (DSEK) in eyes with prior glaucoma surgery. Design: Case-matched retrospective comparative case series. Methods: Setting/study population: 46 DMEK procedures were matched with 46 DSEK procedures at a single institution. Observation procedures: cases were matched based on preoperative visual acuity, lens status, and surgical indication. Main outcome measurements: the outcome measurements included visual acuity improvement, primary and secondary graft failure, endothelial rejection, intraocular pressure (IOP) elevation, and the need for additional glaucoma intervention. Results: Best-corrected visual acuity (BCVA) improved by −0.89 logMAR in the DMEK group and −0.62 logMAR in the DSEK group (P = 0.005) at 1 year follow-up. Visual acuity was significantly better in the DMEK group at postoperative months 1, 3, and 12 and at last follow-up. The percentage of patients achieving 20/40 or better best-corrected visual acuity was higher in the DMEK group at all time points, notably 47% in the DMEK group versus 15% in the DSEK group at 1 year (P = 0.002). Secondary graft failure was lower in the DMEK group (DMEK 0% vs. DSEK 17%; P = 0.006). Primary graft failure rates and rebubling rates were similar. There were no differences in the rates of postoperative IOP elevation or in the need for additional glaucoma intervention. Conclusions: In complex eyes with prior glaucoma surgery, DMEK offers faster visual recovery, better final visual acuity, and a lower rate of secondary graft failure compared to DSEK during the first postoperative year and beyond. © 2019

Subject(s)

Article
 Best corrected visual acuity
 Case control study
 Case study
 Central corneal thickness
 Clinical outcome
 Controlled study
 Descemet membrane endothelial keratoplasty
 Descemet stripping endothelial keratoplasty
 Endothelial keratoplasty
 Endothelial rejection
 Female
 Follow up
 Glaucoma
 Glaucoma surgery
 Graft failure
 Human
 Human cell
 Human tissue
 Intermethod comparison
 Intraocular pressure
 Major clinical study
 Male
 Outcome assessment
 Postoperative complication
 Postoperative intraocular pressure elevation
 Preoperative period
 Priority journal
 Retrospective study
 Surgical technique
 Trabeculectomy
 Aged
 Comparative study
 Complication
 Cornea disease
 Filtering operation
 Glaucoma
 Graft rejection
 Graft survival
 Incidence
 Keratometry
 Procedures
 Prognosis
 Reoperation
 United States
 Visual acuity
 Aged
 Corneal Diseases
 Corneal Topography
 Descemet Stripping Endothelial Keratoplasty
 Female
 Filtering Surgery
 Follow-Up Studies
 Glaucoma
 Graft Rejection
 Graft Survival
 Humans
 Incidence
 Male
 Prognosis
 Reoperation
 Retrospective Studies
 United States
 Visual Acuity

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URI

https://hdl.handle.net/20.500.14740/5140

Collections

Scopus: Year 1983-2021

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