Publication: Novel [5]helicene derivative as reversible and selective Hg2+ fluorescence sensor and its application in human cells
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Issued Date
2023
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File Type
application/pdf
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มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Journal of Photochemistry and Photobiology A: Chemistry. Vol 444, No. (2023)
Suggested Citation
Kaewnok N., Chailek N., Muansrichai W., Wangngae S., Petdum A., Panchan W., Kamkaew A., Sirirak J., Swanglap P., Sooksimuang T., Wanichacheva N. Novel [5]helicene derivative as reversible and selective Hg2+ fluorescence sensor and its application in human cells. Journal of Photochemistry and Photobiology A: Chemistry. Vol 444, No. (2023). doi:10.1016/j.jphotochem.2023.114968 Retrieved from: https://hdl.handle.net/20.500.14740/12450
Other Contributor(s)
Abstract
Mercury pollution and its toxicity pose a grave threat to health. Therefore, developing new approaches for detecting mercury ions (Hg2+) in environmental and biological samples is crucial. Herein, a novel [5]helicene-based fluorescence sensor (M201NHP) was designed and synthesized for rapid, sensitive and specific detection of Hg2+. The sensor exhibits fluorescence quenching with a very large Stokes shift (192 nm) towards Hg2+ in aqueous acetonitrile media. The detection limit of the sensor is estimated to be 1.94 ppb, which is lower than the U.S. EPA specification for the maximum Hg2+ level in drinking water. Moreover, M201NHP offers five cycles of reversibility upon competitive chelation of cysteine. The sensor can also screen for Hg2+ contamination in real water samples and skincare products. Additionally, it can track Hg2+ in potential mercury-accumulated human cell lines derived from brain tumours, embryonic kidneys, skin and liver cancers with low cytotoxicity. These results indicate that M201NHP is a promising Hg2+ sensor that can prevent health risks and environmental impacts caused by mercury pollution. © 2023 Elsevier B.V.