Publication:
Anti-tumorigenicity of dietary α-mangostin in an HT-29 colon cell xenograft model and the tissue distribution of xanthones and their phase II metabolites

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Issued Date

2013

Resource Type

Article

File Type

application/pdf

ISSN

16134125

DOI

10.1002/mnfr.201200539

Other identifier(s)

2-s2.0-84872793155

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Molecular Nutrition and Food Research. Vol 57, No.2 (2013), p.203-211

Suggested Citation

Chitchumroonchokchai C., Thomas-Ahner J.M., Li J., Riedl K.M., Nontakham J., Suksumrarn S., Clinton S.K., Kinghorn A.D., Failla M.L. Anti-tumorigenicity of dietary α-mangostin in an HT-29 colon cell xenograft model and the tissue distribution of xanthones and their phase II metabolites. Molecular Nutrition and Food Research. Vol 57, No.2 (2013), p.203-211. doi:10.1002/mnfr.201200539 Retrieved from: https://hdl.handle.net/20.500.14740/6718

Title

Anti-tumorigenicity of dietary α-mangostin in an HT-29 colon cell xenograft model and the tissue distribution of xanthones and their phase II metabolites

Author(s)

Chitchumroonchokchai C.
 Thomas-Ahner J.M.
 Li J.
 Riedl K.M.
 Nontakham J.
 Suksumrarn S.
 Clinton S.K.
 Kinghorn A.D.
 Failla M.L.

Abstract

Scope: This study investigated the in vivo and in vitro activity of α-mangostin (α-MG), the most abundant xanthone in mangosteen pericarp, on HT-29 cell tumorigenicity, proliferation, and several markers of tumor cell activity, as well as the profile and amounts of xanthones in serum, tumor, liver, and feces. Methods and results: Balb/c nu/nu mice were fed either control diet or diet containing 900 mg α-MG/kg. After 1 week of acclimation to diet, mice were injected subcutaneously with HT-29 cells and fed the same diets ad libitum for an additional 2 or 4 weeks. After 2 and 4 weeks, tumor mass and the concentrations of BcL-2 and β-catenin in tumors of mice fed diet with α-MG were significantly less than in mice fed control diet. Xanthones and their metabolites were identified in serum, tumor, liver, and feces. In vitro treatment of HT-29 cells with α-MG also inhibited cell proliferation and decreased expression of BcL-2 and β-catenin. Conclusion: Our data demonstrate that the anti-neoplastic effect of dietary α-MG is associated with the presence of xanthones in the tumor tissue. Further investigation of the impact of beverages and food products containing xanthones on the prevention of colon cancer or as complementary therapy is merited. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Subject(s)

Antineoplastic agent
 Beta catenin
 Biological marker
 Mangostin
 Protein bcl 2
 Xanthone
 Xanthone derivative
 Animal
 Article
 Bagg albino mouse
 Beverage
 Cell proliferation
 Cell strain HT29
 Cell survival
 Colon tumor
 Diet
 Drug effect
 Drug screening
 Female
 Genetics
 Human
 Metabolism
 Mouse
 Nude mouse
 Tissue distribution
 Animals
 Antineoplastic Agents
 Beta Catenin
 Beverages
 Biological Markers
 Cell Proliferation
 Cell Survival
 Colonic Neoplasms
 Diet
 Female
 HT29 Cells
 Humans
 Mice
 Mice, Inbred BALB C
 Mice, Nude
 Proto-Oncogene Proteins c-bcl-2
 Tissue Distribution
 Xanthones
 Xenograft Model Antitumor Assays
 Garcinia mangostana
 Mus

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URI

https://hdl.handle.net/20.500.14740/6718

Collections

Scopus: Year 1983-2021

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