Publication:
Ethyl cellulose microcapsules for protecting and controlled release of folic acid

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Issued Date

2009

Resource Type

Article

File Type

application/pdf

ISSN

15309932

DOI

10.1208/s12249-009-9305-3

Other identifier(s)

2-s2.0-75549084300

Rights Holder(s)

Scopus

Bibliographic Citation

AAPS PharmSciTech. Vol 10, No.4 (2009), p.1104-1112

Suggested Citation

Prasertmanakit S., Praphairaksit N., Chiangthong W., Muangsin N. Ethyl cellulose microcapsules for protecting and controlled release of folic acid. AAPS PharmSciTech. Vol 10, No.4 (2009), p.1104-1112. doi:10.1208/s12249-009-9305-3 Retrieved from: https://hdl.handle.net/20.500.14740/7705

Title

Ethyl cellulose microcapsules for protecting and controlled release of folic acid

Author(s)

Prasertmanakit S.
 Praphairaksit N.
 Chiangthong W.
 Muangsin N.

Abstract

Ethyl cellulose microcapsules were developed for use as a drug-delivery device for protecting folic acid from release and degradation in the undesirable environmental conditions of the stomach, whilst allowing its release in the intestinal tract to make it available for absorption. The controlled release folic acid-loaded ethyl cellulose microcapsules were prepared by oil-in-oil emulsion solvent evaporation using a mixed solvent system, consisting of a 9:1 (v/v) ratio of acetone:methanol and light liquid paraffin as the dispersed and continuous phase. Span 80 was used as the surfactant to stabilize the emulsion. Scanning electron microscopy revealed that the microcapsules had a spherical shape. However, the particulate properties and in vitro release profile depended on the concentrations of the ethyl cellulose, Span 80 emulsifier, sucrose (pore inducer), and folic acid. The average diameter of the microcapsules increased from 300 to 448μm, whilst the folic acid release rate decreased from 52% to 40%, as the ethyl cellulose concentration was increased from 2.5% to 7.5% (w/v). Increasing the Span 80 concentration from 1% to 4% (v/v) decreased the average diameter of microcapsules from 300 to 141μm and increased the folic acid release rate from 52% to 79%. The addition of 2.5-7.5% (w/v) of sucrose improved the folic acid release from the microcapsules. The entrapment efficiency was improved from 64% to 88% when the initial folic acid concentration was increased from 1 to 3 mg/ml. © 2009 American Association of Pharmaceutical Scientists.

Subject(s)

Acetone
 Ethyl cellulose
 Folic acid
 Liquid paraffin
 Methanol
 Solvent
 Sorbitan oleate
 Sucrose
 Article
 Concentration (parameters)
 Controlled release formulation
 Controlled study
 Dispersion
 Drug absorption
 Drug capsule
 Drug degradation
 Drug delivery system
 Drug release
 Drug stability
 Emulsion
 Evaporation
 High performance liquid chromatography
 In vitro study
 Microencapsulation
 Particle size
 Scanning electron microscopy
 Stomach juice
 Capsules
 Cellulose
 Delayed-Action Preparations
 Emulsions
 Folic Acid
 Hydrogen-Ion Concentration
 Microscopy, Electron, Scanning
 Solubility
 Tablets

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URI

https://hdl.handle.net/20.500.14740/7705

Collections

Scopus: Year 1983-2021

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