Publication:
Antimicrobial activity of 8-hydroxyquinoline and transition metal complexes

1
0

Issued Date

2013

Resource Type

Article

File Type

application/pdf

ISSN

18117775

DOI

10.3923/ijp.2013.170.175

Other identifier(s)

2-s2.0-84878828933

Rights Holder(s)

Scopus

Bibliographic Citation

International Journal of Pharmacology. Vol 9, No.2 (2013), p.170-175

Suggested Citation

Srisung S., Suksrichavalit T., Prachayasittikul S., Ruchirawat S., Prachayasittikul V. Antimicrobial activity of 8-hydroxyquinoline and transition metal complexes. International Journal of Pharmacology. Vol 9, No.2 (2013), p.170-175. doi:10.3923/ijp.2013.170.175 Retrieved from: https://hdl.handle.net/20.500.14740/6640

Title

Antimicrobial activity of 8-hydroxyquinoline and transition metal complexes

Author(s)

Srisung S.
 Suksrichavalit T.
 Prachayasittikul S.
 Ruchirawat S.
 Prachayasittikul V.

Abstract

Heterocyclic compounds like 8-hydroxyquinoline (8HQ) and derivatives have been found in natural products and therapeutics. Herein 8HQ and metal complexes of 8HQ-5-substituted (X) uracils, X = I, N02 (1-6) were investigated for their antimicrobial potency. The complexes 1 -6 exhibited growth inhibition against many strains of gram-positive and gram-negative bacteria with minimum inhibitory concentrations (MICs) of 575.71-718.76 uM. The investigated compound 8HQ was shown to be a very strong antimicrobial agent with the MIC of 27.58 uM that comparable to ampicillin (MIC 26.93 uM), the reference drug. The activity of 8HQ mostly was observed for resistant pathogens, gram- positive bacteria e.g. Staphylococcus aureus, Enterococcus faecalis and diploid fungus, Candida albicans. The findings reveal 8HQ as the very potent antimicrobial agent and a series of 8HQ transition metal complexes as novel antimicrobials as well as the applications of 8HQ for the design and synthesis of new and potential therapeutic lead compounds. © 2013 Asian Network for Scientific Information.

Subject(s)

5 nitrouracil
 8 quinolinol
 8 quinolinol copper 5 iodouracil
 8 quinolinol copper 5 nitrouracil
 8 quinolinol derivative
 8 quinolinol manganese 5 iodouracil
 8 quinolinol manganese 5 nitrouracil
 8 quinolinol nickel 5 iodouracil
 8 quinolinol nickel 5 nitrouracil
 Ampicillin
 Antiinfective agent
 Copper
 Heterocyclic compound
 Iodouracil
 Manganese
 Natural product
 Nickel
 Nitrogen oxide
 Transition element
 Unclassified drug
 Uracil
 Uracil derivative
 Antimicrobial activity
 Article
 Bacterial strain
 Candida albicans
 Complex formation
 Controlled study
 Drug design
 Drug potency
 Drug structure
 Drug synthesis
 Enterococcus faecalis
 Gram negative bacterium
 Gram positive bacterium
 Growth inhibition
 Minimum inhibitory concentration
 Nonhuman
 Staphylococcus aureus

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URI

https://hdl.handle.net/20.500.14740/6640

Collections

Scopus: Year 1983-2021

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