Publication:
Intratympanic dexamethasone for refractory sudden sensorineural hearing loss

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Issued Date

2010

Resource Type

Article

File Type

application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-78650054054

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 93, No.12 (2010), p.1406-1414

Suggested Citation

Hunchaisri N., Chantapant S., Srinangyam N. Intratympanic dexamethasone for refractory sudden sensorineural hearing loss. Journal of the Medical Association of Thailand. Vol 93, No.12 (2010), p.1406-1414. Retrieved from: https://hdl.handle.net/20.500.14740/7486

Title

Intratympanic dexamethasone for refractory sudden sensorineural hearing loss

Author(s)

Hunchaisri N.
 Chantapant S.
 Srinangyam N.

Abstract

Background: The standard medical regimen for SSNHL is systemic steroid therapy. Unfortunately, some patients either do not or poorly respond to systemic steroids. Intratympanic administration of steroids has been suggested as an alternative to systemic therapy. Objective: To determine if intratympanic dexamethasone injection (ITDI) is an effective treatment for sudden sensorineural hearing loss (SSNHL) in patients that systemic steroid treatment has failed. Material and Method: A prospective, non-randomized, controlled study evaluated the hearing outcomes in 14 SSNHL patients treated with ITDI as compared with the outcome of seven patients not treated. Int ratympanic dexamethasone was administered through a spinal needle under local anesthesia. ITDI was performed once every week for maximum of three sessions. Hearing was assessed immediately before the therapy and 4 weeks after the therapy. Results: Hearing improvement was documented in six of 14 patients (43%) who underwent ITDI compare to none of the seven patients (0%) in no ITDI group. However, this was not statistically significant (p = 0.055). Conclusion: Intratympanic dexamethasone (ITDI) may have benefits for patients with SSNHL who failed systemic steroid therapy.

Subject(s)

Betahistine
 Cyanocobalamin
 Dexamethasone
 Mecobalamin
 Prednisolone
 Pyridoxine
 Thiamine
 Adolescent
 Adult
 Aged
 Article
 Clinical article
 Clinical trial
 Controlled clinical trial
 Controlled study
 Drug efficacy
 Drug response
 Eardrum perforation
 Female
 Human
 Infection
 Male
 Pain
 Perception deafness
 Prospective study
 Sudden deafness
 Treatment outcome
 Vertigo
 Administration, Oral
 Administration, Topical
 Adolescent
 Adult
 Aged
 Aged, 80 and over
 Anti-Inflammatory Agents
 Audiometry, Pure-Tone
 Auditory Threshold
 Dexamethasone
 Dose-Response Relationship, Drug
 Female
 Hearing Loss, Sensorineural
 Hearing Loss, Sudden
 Humans
 Male
 Middle Aged
 Prednisolone
 Prospective Studies
 Treatment Outcome
 Tympanic Membrane
 Young Adult

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URI

https://hdl.handle.net/20.500.14740/7486

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Scopus: Year 1983-2021

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