Publication: Acute and maintenance ECT with flupenthixol in refractory schizophrenia: Sustained improvements in psychopathology, quality of life, and social outcomes
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Issued Date
2003
Resource Type
File Type
application/pdf
ISSN
9209964
Other identifier(s)
2-s2.0-0042206786
Rights Holder(s)
Scopus
Bibliographic Citation
Schizophrenia Research. Vol 63, (2003), p.189-193
Suggested Citation
Chanpattana W., Kramer B.A. Acute and maintenance ECT with flupenthixol in refractory schizophrenia: Sustained improvements in psychopathology, quality of life, and social outcomes. Schizophrenia Research. Vol 63, (2003), p.189-193. doi:10.1016/S0920-9964(02)00330-4 Retrieved from: https://hdl.handle.net/20.500.14740/6561
Author(s)
Abstract
Objective: To determine the effects of ECT combined with antipsychotic medication therapy on psychopathology, quality of life, and social functioning in patients with refractory schizophrenia. Method: An open acute (Phase I) and maintenance (Phase II) study of the combination of ECT and flupenthixol in the treatment of 46 schizophrenic patients who were nonresponsive to antipsychotic medication from at least two different classes. Scales used: the Brief Psychiatric Rating Scale (BPRS), the Quality of Life Scale (QLS), Social and Occupational Functioning Assessment Scale (SOFAS), Global Assessment of Functioning (GAF), and Mini-Mental State Exam (MMSE). The duration of Phase II was 1 year. Results: In Phase I, there were marked reductions in the BPRS scores, and substantial increases in the QLS, SOFAS, GAF, and MMSE scores. During Phase II, the BPRS negative symptoms worsened but remained improved from baseline. Changes in other outcome measures were negligible. Conclusion: ECT and MECT combined with flupenthixol were effective in improving psychopathology in patients refractory to antipsychotic medication alone. Ratings of psychopathology, quality of life, and social functioning all improved in Phase I and were generally sustained during Phase II in patients who had remitted. © 2002 Elsevier Science B.V. All rights reserved.
Subject(s)
Flupentixol
Adult
Clinical trial
Conference paper
Controlled clinical trial
Controlled study
Drug efficacy
Electroconvulsive therapy
Human
Major clinical study
Mental disease
Mini mental state examination
Outcomes research
Phase 1 clinical trial
Phase 2 clinical trial
Priority journal
Quality of life
Rating scale
Schizophrenia
Social status
Adult
Clinical trial
Conference paper
Controlled clinical trial
Controlled study
Drug efficacy
Electroconvulsive therapy
Human
Major clinical study
Mental disease
Mini mental state examination
Outcomes research
Phase 1 clinical trial
Phase 2 clinical trial
Priority journal
Quality of life
Rating scale
Schizophrenia
Social status