Publication:
Screening of acetylcholinesterase inhibitory activity in essential oil from Myrtaceae

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Issued Date

2019

Resource Type

Article

File Type

application/pdf

ISSN

1254685

Other identifier(s)

2-s2.0-85062391320

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Thai Journal of Pharmaceutical Sciences. Vol 43, No.1 (2019), p.63-68

Suggested Citation

Petrachaianan T., Chaiyasirisuwan S., Athikomkulchai S., Sareedenchai V. Screening of acetylcholinesterase inhibitory activity in essential oil from Myrtaceae. Thai Journal of Pharmaceutical Sciences. Vol 43, No.1 (2019), p.63-68. Retrieved from: https://hdl.handle.net/20.500.14740/5577

Title

Screening of acetylcholinesterase inhibitory activity in essential oil from Myrtaceae

Author(s)

Petrachaianan T.
 Chaiyasirisuwan S.
 Athikomkulchai S.
 Sareedenchai V.

Abstract

Objective: This research was to investigate acetylcholinesterase inhibitory (AChEI) activity of the essential oil from Myrtaceae and its components. Materials and Methods: The essential oils were extracted from a fresh leave of Myrtaceae plants: Eucalyptus globulus Labill (Eucalyptus), Melaleuca cajuputi Powell (Samed-Khao), Melaleuca citrina (Curtis) Dum. Cours (Bottlebrush tree), Psidium guajava Linn. (Gauva), Syzygium cumini (L.) Skeel (Wha), and Syzygium samarangense (Blume) Merr. and L. M. Perry (Chompoo Nam Dok Mai) by hydrodistillation and analyzed chemical constituent by gas chromatography. The AChE inhibition was determined based on Ellman’s method. Results: The essential oil from M. citrina presented the greatest inhibitory activity (71.77 ± 2.11%) and followed by E. globulus (47.65 ± 2.26%), P. guajava (24.96 ± 2.38%), M. cajuputi (21.18 ± 0.54%), S. cumini (19.97 ± 1.10%), and S. samarangense (13.78 ± 1.52%), respectively. Alpha-pinene was found in the essential oil of 6 species. 1,8-Cineole was the main compound of the essential oil from M. citrina and acts as an active constituent on AChEI. The essential oil from M. cajuputi, S. cumini, and S. samarangense contained a small amount of α-pinene, and without 1,8-cineole, then they were less potency on AChEI. Conclusion: The essential oil containing higher amount of 1,8-cineole presented strong activity to inhibit the AChE. Moreover, there are also other constituents in the essential oils that may affect the AChEI activity and also present synergistic effect for AChEI. © 2019, Faculty of Pharmaceutical Sciences, Chulalongkorn University. All rights reserved.

Subject(s)

Acetylcholinesterase
 Alpha bisabolene
 Alpha phellandrene
 Alpha terpineol acetate
 Alpha thujene
 Amorphene
 Aromadendrene
 Beta bisabolene
 Beta elemene
 Bornyl chloride
 Calamenene
 Camphene
 Caryophyllene derivative
 Cineole
 Cymene
 Epi alpha cadinol
 Epi alpha muurolol
 Essential oil
 Gamma cadinene
 Globulol
 Humulene
 Limonene
 Pinene
 Piperitone
 Plant medicinal product
 Platyphyllos
 Sylvestrene
 Terpinene
 Terpinolene
 Unclassified drug
 Unindexed drug
 Article
 Callistemon
 Controlled study
 Drug screening
 Enzyme activity
 Enzyme inhibition
 Enzyme inhibition assay
 Eucalyptus globulus
 Gas chromatography
 Guava
 Hydrodistillation
 IC50
 Mass fragmentography
 Melaleuca cajuputi
 Melaleuca citrina
 Myrtaceae
 Syzygium cumini
 Syzygium samarangense

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URI

https://hdl.handle.net/20.500.14740/5577

Collections

Scopus: Year 1983-2021

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