Publication:
Effect of Thunbergia laurifolia, a Thai natural product used to treat drug addiction, on cerebral activity detected by functional magnetic resonance imaging in the rat

1
0

Issued Date

2005

Resource Type

Article

File Type

application/pdf

ISSN

333158

DOI

10.1007/s00213-005-0053-0

Other identifier(s)

2-s2.0-24944479105

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Psychopharmacology. Vol 180, No.4 (2005), p.752-760

Suggested Citation

Thongsaard W., Marsden C.A., Morris P., Prior M., Shah Y.B. Effect of Thunbergia laurifolia, a Thai natural product used to treat drug addiction, on cerebral activity detected by functional magnetic resonance imaging in the rat. Psychopharmacology. Vol 180, No.4 (2005), p.752-760. doi:10.1007/s00213-005-0053-0 Retrieved from: https://hdl.handle.net/20.500.14740/6104

Title

Effect of Thunbergia laurifolia, a Thai natural product used to treat drug addiction, on cerebral activity detected by functional magnetic resonance imaging in the rat

Author(s)

Thongsaard W.
 Marsden C.A.
 Morris P.
 Prior M.
 Shah Y.B.

Abstract

Rationale: Thunbergia laurifolia Linn. (TL) is an herbal medicine used to treat alcohol and drug addiction in Thai traditional medicine. A previous study demonstrated that an extract of TL increases rat striatal dopamine release in vitro. Objectives: This study determined whether a methanol extract of TL altered rat brain region activity using in vivo functional nuclear magnetic resonance imaging (fMRI) in a manner consistent with the observed effects in vitro on dopamine release. Methods: fMRI was performed on a 2.35-T Bruker MR system. MR images were acquired from rat brain using the rapid acquisition relaxation enhanced sequence (field of view 50 mm). The imaging parameters used for the anatomical scan yielded an in-plane spatial resolution of 0.2×0.2 mm. Consecutive single-slice functional imaging over the rat brain investigated the changes in signal intensity in various parts of the brains induced by TL (200 mg/kg, i.p.) or vehicle administration. Results: These demonstrate that TL increased signal intensity in various brain areas such as nucleus accumbens, globus pallidus, amygdala, frontal cortex, caudate putamen and hippocampus. These are similar to those reported previously to show effects after either cocaine or amphetamine administration. Physiological variables were not affected by the injection of TL (200 mg/kg, i.p.), but there was a small decrease in arterial blood pressure. Conclusions: The results indicate that TL increases significant neuronal activity in specific brain regions responsible for reward and locomotor behaviour (fixed-effect analysis); however, there is no significant difference between TL and vehicle-treated groups with random-effect analysis (population statistic). The active compound(s) in TL responsible for the pharmacological effects of TL remain to be identified. © Springer-Verlag 2005.

Subject(s)

Natural product
 Plant extract
 Thunbergia laurifolia extract
 Unclassified drug
 Amygdaloid nucleus
 Animal experiment
 Arterial pressure
 Article
 Brain electrophysiology
 Caudate nucleus
 Cocaine dependence
 Controlled study
 Dopamine release
 Drug dependence
 Drug effect
 Drug efficacy
 Drug mechanism
 Frontal cortex
 Functional magnetic resonance imaging
 Globus pallidus
 Hippocampus
 In vivo study
 Instrumentation
 Medicinal plant
 Nerve conduction
 Neuroimaging
 Neuropharmacology
 Nonhuman
 Nucleus accumbens
 Priority journal
 Putamen
 Rat
 Thunbergia laurifolia
 Traditional medicine
 Acanthaceae
 Analysis of Variance
 Animals
 Blood Gas Analysis
 Blood Pressure
 Brain
 Brain Mapping
 Cerebrovascular Circulation
 Functional Laterality
 Image Processing, Computer-Assisted
 Magnetic Resonance Imaging
 Oxygen
 Plant Extracts
 Rats
 Time Factors

View online Resources

Research Projects

Organizational Units

Journal Issue

URI

https://hdl.handle.net/20.500.14740/6104

Collections

Scopus: Year 1983-2021

Endorsement

Review

Supplemented By

Referenced By