Publication:
Alpha-mangostin attenuation of hyperglycemia-induced ocular hypoperfusion and blood retinal barrier leakage in the early stage of type 2 diabetes rats

2
0

Issued Date

2015

Resource Type

Article

File Type

application/pdf

ISSN

23146133

DOI

10.1155/2015/785826

Other identifier(s)

2-s2.0-84928561973

Rights Holder(s)

Scopus

Bibliographic Citation

BioMed Research International. Vol 2015, (2015)

Suggested Citation

Jariyapongskul A., Areebambud C., Suksamrarn S., Mekseepralard C. Alpha-mangostin attenuation of hyperglycemia-induced ocular hypoperfusion and blood retinal barrier leakage in the early stage of type 2 diabetes rats. BioMed Research International. Vol 2015, (2015). doi:10.1155/2015/785826 Retrieved from: https://hdl.handle.net/20.500.14740/6245

Title

Alpha-mangostin attenuation of hyperglycemia-induced ocular hypoperfusion and blood retinal barrier leakage in the early stage of type 2 diabetes rats

Author(s)

Jariyapongskul A.
 Areebambud C.
 Suksamrarn S.
 Mekseepralard C.

Abstract

The present study examined effects of alpha-mangostin (α-MG) supplementation on the retinal microvasculature, including ocular blood flow (OBF) and blood-retinal barrier (BRB) permeability in a type 2 diabetic animal model. Male Sprague-Dawley rats were divided into four groups: normal control and diabetes with or without α-MG supplementation. Alpha-mangostin (200 mg/Kg/day) was administered by gavage feeding for 8 weeks. The effects of α-MG on biochemical and physiological parameters including mean arterial pressure (MAP), OBF, and BRB leakage were investigated. Additionally, levels of retinal malondialdehyde (MDA), advance glycation end products (AGEs), receptor of advance glycation end products (RAGE), tumour necrosis factor alpha (TNF-α), and vascular endothelial growth factor (VEGF) were evaluated. The elevated blood glucose, HbA1c, cholesterol, triglyceride, serum insulin, and HOMA-IR were observed in DM2 rats. Moreover, DM2 rats had significantly decreased OBF but statistically increased MAP and leakage of the BRB. The α-MG-treated DM2 rats showed significantly lower levels of retinal MDA, AGEs, RAGE, TNF-α, and VEGF than the untreated group. Interestingly, α-MG supplementation significantly increased OBF while it decreased MAP and leakage of BRB. In conclusion, α-MG supplementation could restore OBF and improve the BRB integrity, indicating its properties closely associated with antihyperglycemic, antioxidant, anti-inflammatory, and antiglycation activities. © 2015 Amporn Jariyapongskul et al.

Subject(s)

Advanced glycation end product
 Advanced glycation end product receptor
 Alpha mangostin
 Antidiabetic agent
 Antiinflammatory agent
 Antioxidant
 Cholesterol
 Glucose
 Hemoglobin A1c
 Insulin
 Malonaldehyde
 Mangosteen extract
 Plant extract
 Triacylglycerol
 Tumor necrosis factor alpha
 Unclassified drug
 Vasculotropin
 Glucose blood level
 Glycosylated hemoglobin
 Mangostin
 Tumor necrosis factor
 Vasculotropin A
 Xanthone derivative
 Animal experiment
 Animal model
 Antidiabetic activity
 Antiglycation activity
 Antiinflammatory activity
 Antioxidant activity
 Article
 Blood retina barrier
 Cholesterol blood level
 Controlled study
 Diabetic retinopathy
 Drug activity
 Drug effect
 Drug efficacy
 Eye blood flow
 Glucose blood level
 Hemoglobin blood level
 Homeostasis model assessment of insulin resistance
 Hyperglycemia
 Insulin blood level
 Male
 Mean arterial pressure
 Metabolic parameters
 Non insulin dependent diabetes mellitus
 Nonhuman
 Perfusion
 Rat
 Retina blood vessel
 Statistical analysis
 Triacylglycerol blood level
 Animal
 Blood
 Blood retina barrier
 Complication
 Diet therapy
 Drug effects
 Experimental diabetes mellitus
 Human
 Hyperglycemia
 Metabolism
 Non insulin dependent diabetes mellitus
 Pathology
 Pathophysiology
 Animalia
 Rattus
 Animals
 Blood Glucose
 Blood-Retinal Barrier
 Diabetes Mellitus, Experimental
 Diabetes Mellitus, Type 2
 Diabetic Retinopathy
 Hemoglobin A, Glycosylated
 Humans
 Hyperglycemia
 Male
 Rats
 Tumor Necrosis Factor-alpha
 Vascular Endothelial Growth Factor A
 Xanthones

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URI

https://hdl.handle.net/20.500.14740/6245

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Scopus: Year 1983-2021

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