Publication:
Nitrogen plasma skin regeneration for the treatment of mild-to-moderate periorbital wrinkles: A prospective, randomized, controlled evaluator-blinded trial

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Issued Date

2019

Resource Type

Article

File Type

application/pdf

ISSN

14732130

DOI

10.1111/jocd.12767

Other identifier(s)

2-s2.0-85052462913

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Journal of Cosmetic Dermatology. Vol 18, No.1 (2019), p.163-168

Suggested Citation

Theppornpitak N., Udompataikul M., Chalermchai T., Ophaswongse S., Limtanyakul P. Nitrogen plasma skin regeneration for the treatment of mild-to-moderate periorbital wrinkles: A prospective, randomized, controlled evaluator-blinded trial. Journal of Cosmetic Dermatology. Vol 18, No.1 (2019), p.163-168. doi:10.1111/jocd.12767 Retrieved from: https://hdl.handle.net/20.500.14740/5470

Title

Nitrogen plasma skin regeneration for the treatment of mild-to-moderate periorbital wrinkles: A prospective, randomized, controlled evaluator-blinded trial

Author(s)

Theppornpitak N.
 Udompataikul M.
 Chalermchai T.
 Ophaswongse S.
 Limtanyakul P.

Abstract

Background: Nitrogen plasma skin regeneration is a novel device that produces heat to the skin, resulting in the production of new collagen. Because of lower energy with safer skin damage and lesser adverse effects who have high Fitzpatrick's skin type especially Thais, this technique is very interesting for clinical application for skin esthetic treatment. However, this treatment has yet been empirically studied as the treatment for mild-to-moderate periorbital wrinkles. Objectives: This study aimed to evaluate clinical efficacy of nitrogen plasma for the treatment of mild-to-moderate periorbital wrinkles. Methods: Eighteen volunteers were enrolled. Each volunteer was randomized to receive nitrogen plasma treatment on one side of periorbital wrinkles with three sessions at a three-week interval and compared with contralateral side without treatment. Photographic examination, skin wrinkle (SEw) score, melanin index, patients' satisfaction score, side effect, and pain score were reported. Results: At over fourteen weeks, all volunteers completed the study. Treatment with nitrogen plasma group had significantly better improvement for periorbital wrinkles score by Lemperle scale, skin wrinkle (SEw) score by Visioscan® VC 98, and the melanin index by Mexameter® than the control groups (P = 0.004, P < 0.001, P < 0.001, respectively). This study also showed significantly greater satisfaction score to favor the nitrogen plasma treatment group than the control group (P < 0.001). The short-term adverse effects included erythema, scaling, temporary hyperpigmentation, pruritus, and dryness. Conclusion: Nitrogen plasma skin regeneration is effective and safe for the treatment of mild-to-moderate periorbital wrinkles and darkening. © 2018 Wiley Periodicals, Inc.

Subject(s)

Nitrogen
 Nitrogen
 Adult
 Article
 Clinical effectiveness
 Controlled study
 Disease severity
 Dry skin
 Erythema
 Esthetics
 Eye photography
 Female
 General condition improvement
 Human
 Human experiment
 Hyperpigmentation
 Lemperle scale
 Male
 Melanin index
 Middle aged
 Normal human
 Pain assessment
 Patient safety
 Patient satisfaction
 Periorbital wrinkle
 Plasma skin regeneration
 Priority journal
 Prospective study
 Pruritus
 Randomized controlled trial
 Scaling
 Single blind procedure
 Skin disease
 Skin disease assessment
 Skin wrinkle score
 Treatment duration
 Treatment planning
 Wrinkle
 Cutaneous parameters
 Drug effect
 Esthetic surgery
 Eye
 Functions of the skin and its appendages
 Regeneration
 Treatment outcome
 Adult
 Cosmetic Techniques
 Eye
 Female
 Humans
 Male
 Middle Aged
 Nitrogen
 Patient Satisfaction
 Prospective Studies
 Regeneration
 Single-Blind Method
 Skin Aging
 Skin Physiological Phenomena
 Treatment Outcome

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URI

https://hdl.handle.net/20.500.14740/5470

Collections

Scopus: Year 1983-2021

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