Publication:
Vasorelaxant effects of 5,7,4'-Trimethoxyflavone from Kaepmferia parviflora in the rat aorta

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Issued Date

2010

Resource Type

Article

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application/pdf

ISSN

18117775

Other identifier(s)

2-s2.0-77955594981

Rights Holder(s)

Scopus

Bibliographic Citation

International Journal of Pharmacology. Vol 6, No.4 (2010), p.381-386

Suggested Citation

Tep-Areenan P., Sawasdee P. Vasorelaxant effects of 5,7,4'-Trimethoxyflavone from Kaepmferia parviflora in the rat aorta. International Journal of Pharmacology. Vol 6, No.4 (2010), p.381-386. Retrieved from: https://hdl.handle.net/20.500.14740/7552

Title

Vasorelaxant effects of 5,7,4'-Trimethoxyflavone from Kaepmferia parviflora in the rat aorta

Author(s)

Tep-Areenan P.
 Sawasdee P.

Abstract

The aim of the present study was to investigate mechanisms underlying vasorelaxation induced by 5,7,4'-trimethoxyflavone (TMF), a major compound isolated from KPE, in the isolated rat aorta. TMF (1-100 μM) caused concentration-dependent vasorelaxations which were reduced by removal of the endothelium and addition of 300 μM NG-nitro L-arginine methyl ester, or 10 μM 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one. However, the effects of TMF were not inhibited by pretreatment with 10 μM indomethacin, 100 μM aminoguanidine, 100 μM 7-nitroindazole. In addition, vasorelaxnt responses to TMF were inhibited by a high concentration of KCl (60 mM), 5 mM tetraethylammonium and 30 μM barium chloride, but not 10 μM glibenclamide and 1 mM 4-aminopyridine. Interestingly, incubation with TMF (10 and 100 μM) for 30 min significantly inhibited contractions to CaCl2 in a Ca2+-free, high K+ buffer. The present findings have shown for the first time that TMF-induced vasorelaxations are partly mediated via endothelium-derived NO, at least in part, through cGMP-dependent pathway. Moreover, activation of K+ efflux and inhibition of extracellular Ca2+ influx are involved in the vasorelaxant effects of TMF. From these findings, TMF acts as a vasodilator and may play an important role in the vasorelaxant effects of KPE. © 2010 Asian Network for Scientific Information.

Subject(s)

1h 1,2,4 oxadiazolo[4,3 a]quinoxalin 1 one
 4 aminopyridine
 5,7,4' trimethoxyflavone
 7 nitroindazole
 Aminoguanidine
 Barium chloride
 Calcium chloride
 Calcium ion
 Cyclic GMP
 Glibenclamide
 Indometacin
 N(g) nitroarginine methyl ester
 Potassium chloride
 Potassium ion
 Tetrylammonium
 Unclassified drug
 Vasodilator agent
 Animal tissue
 Aorta constriction
 Article
 Calcium transport
 Concentration response
 Controlled study
 Drug mechanism
 Drug structure
 Extracellular calcium
 Kaepmferia parviflora
 Male
 Nonhuman
 Potassium transport
 Rat
 Vasodilatation
 Zingiberaceae

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https://hdl.handle.net/20.500.14740/7552

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