Publication:
The Thai anesthesia incident monitoring study of perioperative allergic reactions: An analysis of 1996 incidents reports

0
0

Issued Date

2008

Resource Type

Article

File Type

application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-55249120206

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 91, No.10 (2008), p.1524-1530

Suggested Citation

Lapisatepun W., Charuluxananan S., Kusumaphanyo C., Ittichaikulthol W., Suksompong S., Ratanachai P. The Thai anesthesia incident monitoring study of perioperative allergic reactions: An analysis of 1996 incidents reports. Journal of the Medical Association of Thailand. Vol 91, No.10 (2008), p.1524-1530. Retrieved from: https://hdl.handle.net/20.500.14740/3894

Title

The Thai anesthesia incident monitoring study of perioperative allergic reactions: An analysis of 1996 incidents reports

Author(s)

Lapisatepun W.
 Charuluxananan S.
 Kusumaphanyo C.
 Ittichaikulthol W.
 Suksompong S.
 Ratanachai P.

Abstract

Objectives: Analyze the clinical course, management, outcome, and contributing factors of perioperative allergic reactions in the Thai Anesthesia Incident Monitoring Study (Thai AIMS). Material and Method: A prospective descriptive multicenter study was conducted in 51 hospitals across Thailand. Voluntary, anonymous reports of any adverse or undesirable events during the first 24 hours of anesthesia were sent to the Thai AIMS data management unit. Possible perioperative allergic reactions were extracted and examined independently by three peer reviewers. Results: Forty-three reports of possible perioperative allergic reactions from the 2,537 incidents reported to the Thai AIMS (1.6%) were reviewed. There was a female predominance (1.9:1). The most common features were cutaneous manifestations (93%), arterial hypotension (20.1%), and bronchospasm (11.6%) respectively. The severity grades were 69.8% in grade I, 4.7% in grade II, and 25.6% in grade III. The three most suspected causative agents were neuromuscular blocking agents (39.5%, 30.2%- succinylcholine), antibiotics (27.9%), and opioids (18.6%) respectively. All but one responded well to treatment with complete recovery. One patient suffered acute myocardial infarction and had to stay at the hospital for longer than one week. None had further allergic reaction. Conclusion: Perioperative allergic reactions accounted for 1.6% of anesthetic adverse events. The most common features were cutaneous manifestations. A quarter of these were life-threatening but responded well to treatment. The most common suspected causative agent was succinylcholine.

Subject(s)

Antibiotic agent
 Antihistaminic agent
 Atracurium
 Bronchodilating agent
 Cephalosporin
 Cloxacillin
 Corticosteroid
 Fentanyl
 Fresh frozen plasma
 Gelatin
 Hypertensive agent
 Metronidazole
 Morphine
 Neuromuscular blocking agent
 Opiate
 Pethidine
 Plasma substitute
 Propofol
 Rocuronium
 Suxamethonium
 Thiopental
 Vecuronium
 Adult
 Article
 Bronchospasm
 Clinical article
 Clinical trial
 Disease severity
 Drug hypersensitivity
 Drug surveillance program
 Erythrocyte concentrate
 Female
 Human
 Hypotension
 Male
 Multicenter study
 Perioperative complication
 Sex difference
 Skin manifestation
 Thailand
 Adolescent
 Adult
 Adverse Drug Reaction Reporting Systems
 Aged
 Aged, 80 and over
 Analgesics, Opioid
 Anesthesia
 Anti-Bacterial Agents
 Child
 Child, Preschool
 Drug Hypersensitivity
 Drug Monitoring
 Female
 Health Status Indicators
 Humans
 Hypersensitivity
 Incidence
 Male
 Middle Aged
 Neuromuscular Agents
 Perioperative Care
 Prospective Studies
 Risk Factors
 Succinylcholine
 Thailand
 Young Adult

View online Resources

Research Projects

Organizational Units

Journal Issue

URI

https://hdl.handle.net/20.500.14740/3894

Collections

Scopus: Year 1983-2021

Endorsement

Review

Supplemented By

Referenced By