Publication:
Comparative trial of 5% dexpanthenol in water-in-oil formulation with 1% hydrocortisone ointment in the treatment of childhood atopic dermatitis: A pilot study

0
0

Issued Date

2012

Resource Type

Article

File Type

application/pdf

ISSN

15459616

Other identifier(s)

2-s2.0-84858672070

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of Drugs in Dermatology. Vol 11, No.3 (2012), p.366-374

Suggested Citation

Udompataikul M., Limpa-O-Vart D. Comparative trial of 5% dexpanthenol in water-in-oil formulation with 1% hydrocortisone ointment in the treatment of childhood atopic dermatitis: A pilot study. Journal of Drugs in Dermatology. Vol 11, No.3 (2012), p.366-374. Retrieved from: https://hdl.handle.net/20.500.14740/7100

Title

Comparative trial of 5% dexpanthenol in water-in-oil formulation with 1% hydrocortisone ointment in the treatment of childhood atopic dermatitis: A pilot study

Author(s)

Udompataikul M.
 Limpa-O-Vart D.

Abstract

Background: Atopic dermatitis (AD) is a common chronic relapsing disease particularly affecting children. The emollient used for protection of skin barrier function is the standard treatment for patients with AD. Currently, there is a growing interest in the use of nonsteroidal anti-inflammatory agents such as dexpanthenol (vitamin B5) as an alternative treatment. Objective: To compare the effectiveness of 5% dexpanthenol (DT) ointment with 1% hydrocortisone (HC) ointment in childhood AD therapy. Method: Patients were treated topically with 5% DT ointment on the right side of the body and 1% HC ointment on the other side twice daily for 4 weeks. The clinical responses were evaluated by SCORAD (Scoring Atopic Dermatitis index) with statistical analysis using paired t-test. Result: Of the 30 children enrolled, 26 completed the protocol; mean age was 7.19 years. The average baseline SCORAD score of the DT-treated side and the HC-treated side was 30.95 and 30.54, respectively. There was no statistically significant difference in SCORAD score reduction between the 2 agents. The edematous score of the HC-treated side exhibited faster resolution than that of the DT-treated side, with a statistically significant difference at week 1 and without a statistically significant difference at weeks 2 to 4. The lichenification response rate of HC treatment was more rapid than that of DT treatment; however, there was no statistical group difference. No adverse events were observed with either agent. Conclusion: The effectiveness of 5% DT ointment is equal to that of 1% HC ointment. DT ointment may be used as alternative treatment in mild to moderate childhood AD therapy. Copyright © 2012 Journal of Drugs in Dermatology.

Subject(s)

Dexpanthenol
 Hydrocortisone
 Water oil cream
 Absence of side effects
 Adolescent
 Age distribution
 Article
 Atopic dermatitis
 Child
 Clinical article
 Controlled study
 Disease severity
 Drug efficacy
 Drug formulation
 Female
 Human
 Lichenoid eruption
 Male
 Ointment
 Pilot study
 Preschool child
 Randomized controlled trial
 School child
 Scoring system
 Single blind procedure
 Skin absorption
 Student t test
 Treatment duration
 Treatment response
 Administration, Cutaneous
 Adolescent
 Case-Control Studies
 Child
 Child, Preschool
 Dermatitis, Atopic
 Dermatologic Agents
 Female
 Humans
 Hydrocortisone
 Infant
 Male
 Ointments
 Pantothenic Acid
 Pilot Projects
 Single-Blind Method
 Time Factors
 Treatment Outcome

View online Resources

Research Projects

Organizational Units

Journal Issue

URI

https://hdl.handle.net/20.500.14740/7100

Collections

Scopus: Year 1983-2021

Endorsement

Review

Supplemented By

Referenced By