Publication:
Acute effects of bergamot oil on anxiety-related behaviour and corticosterone level in rats

2
0

Issued Date

2011

Resource Type

Article

File Type

application/pdf

ISSN

0951418X

DOI

10.1002/ptr.3325

Other identifier(s)

2-s2.0-79957809174

Rights Holder(s)

Scopus

Bibliographic Citation

Phytotherapy Research. Vol 25, No.6 (2011), p.858-862

Suggested Citation

Saiyudthong S., Marsden C.A. Acute effects of bergamot oil on anxiety-related behaviour and corticosterone level in rats. Phytotherapy Research. Vol 25, No.6 (2011), p.858-862. doi:10.1002/ptr.3325 Retrieved from: https://hdl.handle.net/20.500.14740/7320

Title

Acute effects of bergamot oil on anxiety-related behaviour and corticosterone level in rats

Author(s)

Saiyudthong S.
 Marsden C.A.

Abstract

Bergamot essential oil (BEO), Citrus aurantium subsp. bergamia (Risso) Wright & Arn. (Rutaceae), is used widely in aromatherapy to reduce stress and anxiety despite limited scientific evidence. A previous study showed that BEO significantly increased gamma-aminobutyric acid levels in rat hippocampus, suggesting potential anxiolytic properties. The aim of this study was to investigate the effect of BEO (1.0%, 2.5% and 5.0% w/w) administered to rats on both anxiety-related behaviours (the elevated plus-maze (EPM) and hole-board tests) and stress-induced levels of plasma corticosterone in comparison with the effects of diazepam. Inhalation of BEO (1% and 2.5%) and injection of diazepam (1 mg/kg, i.p.) significantly increased the percentage of open arm entries on the EPM. The percentage time spent in the open arms was also significantly enhanced following administration of either BEO (2.5% and 5%) or diazepam. Total arm entries were significantly increased with the highest dose (5%), suggesting an increase in locomotor activity. In the hole-board test, 2.5% BEO and diazepam significantly increased the number of head dips. 2.5% BEO and diazepam attenuated the corticosterone response to acute stress caused by exposure to the EPM. In conclusion, both BEO and diazepam exhibited anxiolytic-like behaviours and attenuated HPA axis activity by reducing the corticosterone response to stress. Copyright © 2010 John Wiley & Sons, Ltd.

Subject(s)

4 aminobutyric acid
 4 aminobutyric acid A receptor
 Bergamot oil
 Corticosterone
 Diazepam
 Acute stress
 Animal experiment
 Animal model
 Anxiety
 Anxiety disorder
 Aromatherapy
 Article
 Controlled study
 Corticosterone blood level
 Emotion
 GABAergic system
 Hypothalamic paraventricular nucleus
 Locomotion
 Male
 Maze test
 Neurotransmission
 Nonhuman
 Rat
 Task performance
 Tranquilizing activity
 Administration, Inhalation
 Animals
 Anti-Anxiety Agents
 Anxiety Disorders
 Corticosterone
 Diazepam
 Male
 Maze Learning
 Oils, Volatile
 Plant Extracts
 Plant Oils
 Rats
 Rats, Wistar
 Citrus aurantium
 Rattus
 Rutaceae

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URI

https://hdl.handle.net/20.500.14740/7320

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Scopus: Year 1983-2021

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