Publication:
Relationship between circadian clock genes and the neurotrophic factor genes in rat hippocampus

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Issued Date

2017

Resource Type

Article

File Type

application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-85075002985

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 100, No.10 (2017), p.S32-S39

Suggested Citation

Pramong R., Govitrapong P., Phansuwan-Pujito P. Relationship between circadian clock genes and the neurotrophic factor genes in rat hippocampus. Journal of the Medical Association of Thailand. Vol 100, No.10 (2017), p.S32-S39. Retrieved from: https://hdl.handle.net/20.500.14740/4476

Title

Relationship between circadian clock genes and the neurotrophic factor genes in rat hippocampus

Author(s)

Pramong R.
 Govitrapong P.
 Phansuwan-Pujito P.

Abstract

Background: The hippocampus, a key brain area for learning and memory, can express clock genes with circadian fashion. The neurotrophic factors are important for cognitive function in the hippocampus. The expression of circadian clock gene and neurotrophic factor in the hippocampus would be necessary to achieve and optimize daily memory performance. Objective: It is of interest to examine the daily expression patterns of neurotrophic factor genes and the link between these genes and clock genes in rat hippocampus. Material and Method: Daily expression profiles of four clock genes (Per1, Cry1, Bmal1, and Rev-erb alpha) and four neurotrophic factor genes (BDNF, NGF, NT-3, and VEGF) were analyzed in the rat hippocampus at 6 hours apart by real-time PCR. Results: The mRNAs of BDNF, NGF, and VEGF, but not NT-3 in hippocampus were expressed in circadian manner as well as those of clock genes. Correlation analysis revealed strong relationships between the expression of VEGF and Per1, VEGF and Rev-erb alpha, BDNF and Bmal1, and BDNF and Cry1. Conclusion: The present study suggests that VEGF and BDNF are clock-controlled genes relating to specific clock genes. Therefore, further investigation on the molecular mechanisms linking cognitive processes and circadian clock in hippocampus could be necessary to clarify their functions. © 2017 Medical Association of Thailand. All rights reserved.

Subject(s)

Brain derived neurotrophic factor
 Cryptochrome 1
 Messenger RNA
 Nerve growth factor
 Neurotrophic factor
 Nuclear receptor NR1D1
 PER1 protein
 Transcription factor ARNTL
 Vasculotropin
 Adult
 Animal experiment
 Animal tissue
 Article
 Bdnf gene
 Bmal1 gene
 Circadian clock gene
 Circadian rhythm
 Controlled study
 Cry1 gene
 Gene
 Gene expression
 Gene expression profiling
 Hippocampus
 MRNA expression assay
 Neurotrophic factor gene
 Nonhuman
 Per1 gene
 Protein expression
 Rat
 Real time reverse transcription polymerase chain reaction
 Rev-erb alpha gene
 RNA isolation
 Vegf gene

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URI

https://hdl.handle.net/20.500.14740/4476

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Scopus: Year 1983-2021

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