Publication: Barakol: A potential anxiolytic extracted from Cassia siamea
8
0
Issued Date
1996
Resource Type
File Type
application/pdf
ISSN
913057
Other identifier(s)
2-s2.0-0029986763
Rights Holder(s)
Scopus
Bibliographic Citation
Pharmacology Biochemistry and Behavior. Vol 53, No.3 (1996), p.753-758
Suggested Citation
Thongsaard W., Deachapunya C., Pongsakorn S., Boyd E.A., Bennett G.W., Marsden C.A. Barakol: A potential anxiolytic extracted from Cassia siamea. Pharmacology Biochemistry and Behavior. Vol 53, No.3 (1996), p.753-758. doi:10.1016/0091-3057(95)02088-8 Retrieved from: https://hdl.handle.net/20.500.14740/7406
Abstract
The behavioural effects of an extract of Cassia siamea, a plant used in Thai traditional medicine, and barakol, its active chemical, were studied on an elevated plus-maze compared with diazepam. An aqueous extract of C. siamea (1, 6, and 12 g/kg body wt., orally) produced a small increase in the percentage of the open : total number of arm entries and time, time spent on the end of the open arms, total number of arm entries, and number of rears/min. Barakol [10 mg/kg, intraperitoneally (IP)] significantly increased all of these behavioural parameters in a manner similar to diazepam (1 mg/kg, IF, 30 or 60 min before testing), except that barakol and not diazepam increased both the number of rears and total arm entries. Barakol at 25 and 50 mg/kg increased the percentage of the open : total number of arm entries and time and number of rears. The results indicate that barakol has anxiolytic properties similar to diazepam but differs from diazepam in that it also increases exploratory and locomotor behaviour, as shown by the number of rears and total arm entries.
Subject(s)
Anxiolytic agent
Barakol
Cassia extract
Cassia siamea extract
Diazepam
Plant extract
Unclassified drug
Animal experiment
Article
Behavior
Controlled study
Exploratory behavior
Intraperitoneal drug administration
Locomotion
Male
Maze test
Nonhuman
Oral drug administration
Priority journal
Rat
Thailand
Traditional medicine
Tranquilizing activity
Animalia
Cassia
Senna siamea
Barakol
Cassia extract
Cassia siamea extract
Diazepam
Plant extract
Unclassified drug
Animal experiment
Article
Behavior
Controlled study
Exploratory behavior
Intraperitoneal drug administration
Locomotion
Male
Maze test
Nonhuman
Oral drug administration
Priority journal
Rat
Thailand
Traditional medicine
Tranquilizing activity
Animalia
Cassia
Senna siamea