Publication:
Chronic effect of thunbergia laurifolia extract and cocaine in rats using behavior model of addiction

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Issued Date

2015

Resource Type

Article

File Type

application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-84957631112

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 98, (2015), p.S48-S52

Suggested Citation

Thongsaard W., Sangpayap R., Marsden C. Chronic effect of thunbergia laurifolia extract and cocaine in rats using behavior model of addiction. Journal of the Medical Association of Thailand. Vol 98, (2015), p.S48-S52. Retrieved from: https://hdl.handle.net/20.500.14740/6065

Title

Chronic effect of thunbergia laurifolia extract and cocaine in rats using behavior model of addiction

Author(s)

Thongsaard W.
 Sangpayap R.
 Marsden C.

Abstract

Background: Thunbergia laurifolia Linn. (TL) is a herbal medicine which has been used as a component of a mixture of crude extracts to treat drug addicted patients. TL extract was reported to increase dopamine levels significantly in the rat brain both in vitro and in vivo studies similar to that seen with cocaine and TL stimulated in the same brain area that amphetamine stimulated. Objective: The study aims to investigate whether long term treatment with TL can cause addiction or not by comparing with known addicted drug, cocaine, using the conditioned place preference test. Material and Method: Chronic oral administration (30 days) of crude water extract of TL (1 and 10 g/kg, orally) and cocaine (1 mg/kg, orally) were performed to determine the alteration of addiction behavior using a conditioned place preference (CPP) test. Results: Rats received chronic treatment of cocaine became addicted. While, both doses of TL (1 and 10 g/kg, orally) did not cause significantly in the time spent in both compartment between pre- and post-drug treatment. Conclusion: When treated long-term and tested with CPP test of addiction, rats received chronic treatment of cocaine became addicted. On the other hand, both doses of crude water extract of TL (1 and 10 g/kg, orally) did not cause significant changed in the time spent in both compartment between pre- and post- drug treatment indicating that TL did not cause addiction. © 2015, Medical Association of Thailand. All rights reserved.

Subject(s)

Amphetamine
 Cocaine
 Plant extract
 Thunbergia laurifolia extract
 Unclassified drug
 Water
 Cocaine
 Dopamine
 Plant extract
 Animal model
 Article
 Behavior assessment
 Conditioned place preference test
 Controlled study
 Drug dependence
 Functional magnetic resonance imaging
 Long term care
 Nonhuman
 Nucleus accumbens
 Plant leaf
 Rat
 Acanthaceae
 Animal
 Brain
 Chemistry
 Comparative study
 Drug effects
 Male
 Metabolism
 Substance-Related Disorders
 Wistar rat
 Acanthaceae
 Animals
 Brain
 Cocaine
 Dopamine
 Male
 Plant Extracts
 Rats
 Rats, Wistar
 Substance-Related Disorders

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URI

https://hdl.handle.net/20.500.14740/6065

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Scopus: Year 1983-2021

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