Publication: Evaluation of the Role of PRP in Acute Tibial Shaft Fractures Fixation With IM Nail: A Double-Blinded Randomized Controlled Trial
0
0
Issued Date
2025-01-01
Resource Type
ISSN
20903464
eISSN
20903472
Scopus ID
2-s2.0-105002134565
Journal Title
Advances in Orthopedics
Volume
2025
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Advances in Orthopedics Vol.2025 No.1 (2025)
Suggested Citation
Boonyanuwat W., Engkapawastr B.A., Kongmalai P. Evaluation of the Role of PRP in Acute Tibial Shaft Fractures Fixation With IM Nail: A Double-Blinded Randomized Controlled Trial. Advances in Orthopedics Vol.2025 No.1 (2025). doi:10.1155/aort/5642601 Retrieved from: https://hdl.handle.net/20.500.14740/20797
Author(s)
Author's Affiliation
Corresponding Author(s)
Other Contributor(s)
Abstract
Introduction: Tibial shaft fractures, particularly those classified as AO 42-C3, represent a significant orthopedic challenge due to their high risk of delayed union or nonunion. Intramedullary nailing is a widely used treatment, though optimizing biological healing remains essential. Platelet-rich plasma (PRP), containing abundant growth factors, has been suggested as a therapeutic aid to enhance fracture healing. Methods: A randomized controlled trial was conducted, including 32 patients diagnosed with acute AO 42-C3 pure diaphyseal tibial fractures. Patients were randomized into two groups: 16 received PRP injections, while 16 received normal saline solution (NSS) injections as a control. The primary outcome, cortex-to-callus ratio, was assessed via radiographs over a 6-month follow-up. Secondary outcomes included patient-reported measures such as the SF-36 and EQ-5D-3L questionnaires and time to union. Results: The PRP group exhibited a significantly higher cortex-to-callus ratio during the third and fourth months of follow-up (p < 0.05), indicating accelerated callus formation. Moreover, the PRP group exhibited a statistically significant reduction in time to union compared with the NSS group (p < 0.05). Although other patient-reported outcomes did not show significant differences, the PRP group displayed an upward trend in SF-36 scores (p < 0.05). Discussion: PRP significantly enhances midstage fracture healing in tibial shaft fractures, as evidenced by improved callus formation and reduced time to union. These results indicate that PRP holds promise as a therapeutic adjunct for managing tibial fractures. Additional studies with larger sample sizes and diverse fixation techniques are needed to validate these findings and further assess the broader potential of PRP in orthopedic practice.