Publication:
Direct renin inhibition modulates insulin resistance in caveolin-1-deficient mice

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Issued Date

2013

Resource Type

Article

File Type

application/pdf

ISSN

260495

DOI

10.1016/j.metabol.2012.07.013

Other identifier(s)

2-s2.0-84872676454

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Metabolism: Clinical and Experimental. Vol 62, No.2 (2013), p.275-281

Suggested Citation

Chuengsamarn S., Garza A.E., Krug A.W., Romero J.R., Adler G.K., Williams G.H., Pojoga L.H. Direct renin inhibition modulates insulin resistance in caveolin-1-deficient mice. Metabolism: Clinical and Experimental. Vol 62, No.2 (2013), p.275-281. doi:10.1016/j.metabol.2012.07.013 Retrieved from: https://hdl.handle.net/20.500.14740/6722

Title

Direct renin inhibition modulates insulin resistance in caveolin-1-deficient mice

Author(s)

Chuengsamarn S.
 Garza A.E.
 Krug A.W.
 Romero J.R.
 Adler G.K.
 Williams G.H.
 Pojoga L.H.

Abstract

Objective: To test the hypothesis that aliskiren improves the metabolic phenotype in a genetic mouse model of the metabolic syndrome (the caveolin-1 (cav-1) knock out (KO) mouse). Materials/Methods: Eleven-week-old cav-1 KO and genetically matched wild-type (WT) mice were randomized to three treatment groups: placebo (n = 8/group), amlodipine (6 mg/kg/day, n = 18/ group), and aliskiren (50 mg/kg/day, n = 18/ group). After three weeks of treatment, all treatment groups were assessed for several measures of insulin resistance (fasting insulin and glucose, HOMA-IR, and the response to an intraperitoneal glucose tolerance test (ipGTT)) as well as for triglyceride levels and the blood pressure response to treatment. Results: Treatment with aliskiren did not affect the ipGTT response but significantly lowered the HOMA-IR and insulin levels in cav-1 KO mice. However, treatment with amlodipine significantly degraded the ipGTT response, as well as the HOMA-IR and insulin levels in the cav-1 KO mice. Aliskiren also significantly lowered triglyceride levels in the cav-1 KO but not in the WT mice. Moreover, aliskiren treatment had a significantly greater effect on blood pressure readings in the cav-1 KO vs. WT mice, and was marginally more effective than amlodipine. Conclusions: Our results support the hypothesis that aliskiren reduces insulin resistance as indicated by improved HOMA-IR in cav-1 KO mice whereas amlodipine treatment resulted in changes consistent with increased insulin resistance. In addition, aliskiren was substantially more effective in lowering blood pressure in the cav-1 KO mouse model than in WT mice and marginally more effective than amlodipine. © 2013 Elsevier Inc.

Subject(s)

Aliskiren
 Amlodipine
 Caveolin 1
 Glucose
 Insulin
 Placebo
 Triacylglycerol
 Animal cell
 Animal experiment
 Animal model
 Animal tissue
 Article
 Blood pressure regulation
 Controlled study
 Glucose blood level
 Glucose tolerance test
 Insulin blood level
 Insulin resistance
 Male
 Metabolic syndrome X
 Mouse
 Nonhuman
 Phenotype
 Priority journal
 Treatment duration
 Treatment response
 Triacylglycerol blood level
 Wild type
 Amides
 Animals
 Antihypertensive Agents
 Blood Glucose
 Blood Pressure
 Caveolin 1
 Disease Models, Animal
 Fumarates
 Glucose Tolerance Test
 Insulin
 Insulin Resistance
 Male
 Metabolic Syndrome X
 Mice
 Mice, Knockout
 Random Allocation
 Renin
 Triglycerides

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URI

https://hdl.handle.net/20.500.14740/6722

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Scopus: Year 1983-2021

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