Publication:
Electrospray fabrication of doxorubicin-chitosan-tripolyphosphate nanoparticles for delivery of doxorubicin

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Issued Date

2011

Resource Type

Article

File Type

application/pdf

ISSN

2536269

DOI

10.1007/s12272-011-0408-5

Other identifier(s)

2-s2.0-79960414044

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Archives of Pharmacal Research. Vol 34, No.4 (2011), p.583-592

Suggested Citation

Songsurang K., Praphairaksit N., Siraleartmukul K., Muangsin N. Electrospray fabrication of doxorubicin-chitosan-tripolyphosphate nanoparticles for delivery of doxorubicin. Archives of Pharmacal Research. Vol 34, No.4 (2011), p.583-592. doi:10.1007/s12272-011-0408-5 Retrieved from: https://hdl.handle.net/20.500.14740/7352

Title

Electrospray fabrication of doxorubicin-chitosan-tripolyphosphate nanoparticles for delivery of doxorubicin

Author(s)

Songsurang K.
 Praphairaksit N.
 Siraleartmukul K.
 Muangsin N.

Abstract

This work focused on a new technique for the preparation of doxorubicin (DOX) loaded chitosan (CS) nanoparticles (DOX-CS) - formation by electrospray ionization in the presence of tripolyphosphate (TPP) as the stabilizer. The working distance, needle gauge, flow rate, stirring rate, electrospraying voltage and DOX to CS molar ratio were sequentially and individually optimized and found to be a 26 gauge needle, an applied voltage of 13 kV, a flow rate of 0.5 mL/h, a working distance of 8 cm and a stirring rate of 400 rpm. The incorporation of chemically unchanged DOX with the CS into the particles was ascertained by Fourier transformed infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Under these optimized conditions, the DOX-CS particles were found to be nanoparticles of approximately 300 - 570 (dry particles) or 530 - 870 nm diameter (hydrated particles), with a PDI and SPAN polydispersity indices of 0.97 - 0.82 and 0.62 - 0.64, respectively, for initial DOX loading levels of 0.25 - 1%, as determined by SEM and particle size analyzer, respectively. Moreover, a high encapsulation efficiency (EE) of DOX into the nanoparticles was attained, ranging from 63.4 to 67.9% EE at 1 to 0.25% DOX loading. Finally, the in vitro DOX release behaviors of the DOX-CS particles revealed a prolonged release of DOX over at least seven hours.

Subject(s)

Chitosan
 Doxorubicin
 Nanoparticle
 Tripolyphosphate
 Article
 Differential scanning calorimetry
 Drug delivery system
 Drug release
 Electrospray
 Encapsulation
 In vitro study
 Infrared spectroscopy
 Particle size
 Thermogravimetry
 Antibiotics, Antineoplastic
 Calorimetry, Differential Scanning
 Chitosan
 Doxorubicin
 Drug Carriers
 Drug Compounding
 Equipment Design
 Microscopy, Electron, Scanning
 Nanoparticles
 Particle Size
 Polyphosphates
 Solubility
 Spectrometry, Mass, Electrospray Ionization
 Spectroscopy, Fourier Transform Infrared
 Surface Properties
 Thermogravimetry

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URI

https://hdl.handle.net/20.500.14740/7352

Collections

Scopus: Year 1983-2021

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