Publication:
Estrogen enhances the number of nigral dopaminergic neurons of adult male mice without affecting nigral neuroglial number and morphology

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Issued Date

2008

Resource Type

Article

File Type

application/pdf

ISSN

3043940

DOI

10.1016/j.neulet.2008.02.038

Other identifier(s)

2-s2.0-41549112790

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Neuroscience Letters. Vol 435, No.3 (2008), p.210-214

Suggested Citation

Tripanichkul W., Jaroensuppaperch E.-O., Finkelstein D.I. Estrogen enhances the number of nigral dopaminergic neurons of adult male mice without affecting nigral neuroglial number and morphology. Neuroscience Letters. Vol 435, No.3 (2008), p.210-214. doi:10.1016/j.neulet.2008.02.038 Retrieved from: https://hdl.handle.net/20.500.14740/4045

Title

Estrogen enhances the number of nigral dopaminergic neurons of adult male mice without affecting nigral neuroglial number and morphology

Author(s)

Tripanichkul W.
 Jaroensuppaperch E.-O.
 Finkelstein D.I.

Abstract

Emerging evidence indicate the modulating effects of estrogen on dopaminergic neurons in the substantia nigra pars compacta (SNpc). One of the mechanisms underlying the effect of estrogen is through neuroglia. To determine whether estrogen affects the number of dopaminergic neurons and reactive astrocytes and microglia in the SNpc of male mice, 14-week-old C57Bl/6 male mice were injected with 17β-estradiol (E2) or vehicle for 10.5 days. On day 11 all mice were killed and the SNpc were collected and processed for lectin (GSI-B4) histochemistry, tyrosine hydroxylase (TH) immunohistochemistry or glial fibrillary acidic protein (GFAP) immunohistochemistry. Quantitative studies demonstrated that E2 significantly increases the number of TH-immunoreactive (IR) neurons in the SNpc but the hormone induces no change either in cell number or cell morphology of GFAP-IR astroglia and GSI-B4+ve microglia. These observations suggest that E2 can influence the number of nigral dopaminergic neurons of male mice and possibly protects dopaminergic neuronal loss during normal aging and in Parkinson's disease. © 2008 Elsevier Ireland Ltd. All rights reserved.

Subject(s)

Estradiol
 Glial fibrillary acidic protein
 Lectin
 Tyrosine 3 monooxygenase
 Animal cell
 Animal experiment
 Animal tissue
 Article
 Cell count
 Cell structure
 Controlled study
 Dopaminergic nerve cell
 Drug effect
 Glia cell
 Male
 Mouse
 Nonhuman
 Priority journal
 Substantia nigra
 Animals
 Cell Count
 Cell Proliferation
 Cell Size
 Dopamine
 Estradiol
 Estrogens
 Glial Fibrillary Acidic Protein
 Glycoproteins
 Male
 Mice
 Mice, Inbred C57BL
 Neuroglia
 Neurons
 Substantia Nigra
 Tyrosine 3-Monooxygenase

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URI

https://hdl.handle.net/20.500.14740/4045

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Scopus: Year 1983-2021

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