Publication: A new pyrrole alkaloid from the roots of Cissampelos pareira
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Issued Date
2021
Resource Type
File Type
application/pdf
ISSN
14786419
Other identifier(s)
2-s2.0-85098625668
Rights
Srinakharinwirot University
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Natural Product Research. Vol 35, No.1 (2021), p.80-87
Suggested Citation
Rukachaisirikul T., Kumjun S., Suebsakwong P., Apiratikul N., Suksamrarn A. A new pyrrole alkaloid from the roots of Cissampelos pareira. Natural Product Research. Vol 35, No.1 (2021), p.80-87. doi:10.1080/14786419.2019.1614576 Retrieved from: https://hdl.handle.net/20.500.14740/4767
Abstract
Phytochemical investigation of the roots of Cissampelos pareira Linn. led to the isolation of one new pyrrole alkaloid, cissampeline (1), together with ten known alkaloids, (−)-curine (2), (−)-cyclanoline (3), (+)-tetrandrine (4), (+)-obaberine (5), (+)-obamegine (6), (−)-oblongine (7), (+)-homoaromoline (8), (−)-nor-N׳-chondrocurine (9), trans-N-feruloyltyramine (10) and (+)-coclaurine (11). Their structures were elucidated by extensive NMR and MS spectroscopic analyses. Interestingly, compound 1 represents the first example of pyrrole alkaloid found in the genus Cissampelos. Moreover, compounds 5-11 were isolated for the first time from this genus. Among them, compound 6 showed the highest anti-acetylcholinesterase activity with an IC50 value of 3.26 µM, whereas compound 8 displayed the most potent cytotoxicity against human colon cancer (HT29) cells with an IC50 value of 7.89 µM. © 2019 Informa UK Limited, trading as Taylor & Francis Group.