Publication:
Prevention of Necrotizing Enterocolitis Through Manipulation of the Intestinal Microbiota of the Premature Infant

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Issued Date

2016

Resource Type

Review

File Type

application/pdf

ISSN

1492918

DOI

10.1016/j.clinthera.2016.01.006

Other identifier(s)

2-s2.0-84957927263

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Clinical Therapeutics. Vol 38, No.4 (2016), p.716-732

Suggested Citation

Vongbhavit K., Underwood M.A. Prevention of Necrotizing Enterocolitis Through Manipulation of the Intestinal Microbiota of the Premature Infant. Clinical Therapeutics. Vol 38, No.4 (2016), p.716-732. doi:10.1016/j.clinthera.2016.01.006 Retrieved from: https://hdl.handle.net/20.500.14740/5504

Title

Prevention of Necrotizing Enterocolitis Through Manipulation of the Intestinal Microbiota of the Premature Infant

Author(s)

Vongbhavit K.
 Underwood M.A.

Abstract

Purpose In spite of four decades of research, necrotizing enterocolitis (NEC) remains the most common gastrointestinal complication in premature infants with high mortality and long-term morbidity. The composition of the intestinal microbiota of the premature infant differs dramatically from that of the healthy term infant and appears to be an important risk factor for NEC. Methods We review the evidence of an association between intestinal dysbiosis and NEC and summarize published English language clinical trials and cohort studies involving attempts to manipulate the intestinal microbiota in premature infants. Findings Promising NEC prevention strategies that alter the intestinal microbiota include probiotics, prebiotics, synbiotics, lacteroferrin, and human milk feeding. Implications Shaping the intestinal microbiota of the premature infant through human milk feeding and dietary supplements decreases the risk of NEC. Further studies to identify the ideal microbial composition and the most effective combination of supplements are indicated. © 2016 Elsevier HS Journals, Inc. All rights reserved.

Subject(s)

Lactoferrin
 Prebiotic agent
 Probiotic agent
 Synbiotic agent
 Bacterial colonization
 Bacterial genome
 Breast milk
 Dietary supplement
 Disease association
 Dysbiosis
 Human
 Intestine flora
 Lactobacillus
 Necrotizing enterocolitis
 Outcome assessment
 Prematurity
 Review
 Risk assessment
 Risk factor
 Saccharomyces
 Treatment response
 Enterocolitis, Necrotizing
 Immunology
 Infant
 Newborn
 Physiology
 Dysbiosis
 Enterocolitis, Necrotizing
 Gastrointestinal Microbiome
 Humans
 Infant
 Infant, Newborn
 Infant, Premature

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URI

https://hdl.handle.net/20.500.14740/5504

Collections

Scopus: Year 1983-2021

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Review

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