Publication:
Expression profiles of human CCN genes in patients with osteoarthritis or rheumatoid arthritis

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Issued Date

2015

Resource Type

Article

File Type

application/pdf

ISSN

9492658

DOI

10.1007/s00776-015-0727-3

Other identifier(s)

2-s2.0-84938994511

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of Orthopaedic Science. Vol 20, No.4 (2015), p.708-716

Suggested Citation

Komatsu M., Nakamura Y., Maruyama M., Abe K., Watanapokasin R., Kato H. Expression profiles of human CCN genes in patients with osteoarthritis or rheumatoid arthritis. Journal of Orthopaedic Science. Vol 20, No.4 (2015), p.708-716. doi:10.1007/s00776-015-0727-3 Retrieved from: https://hdl.handle.net/20.500.14740/6121

Title

Expression profiles of human CCN genes in patients with osteoarthritis or rheumatoid arthritis

Author(s)

Komatsu M.
 Nakamura Y.
 Maruyama M.
 Abe K.
 Watanapokasin R.
 Kato H.

Abstract

Objective: Osteoarthritis (OA) and rheumatoid arthritis (RA) are widespread disabling joint disorders that are considered to be polygenic in nature. This study investigated the spatial expression patterns of all six known human CCN genes using end-stage OA and RA joint samples. Design: We performed in situ hybridization and histological analysis to investigate the spatial expression patterns of human CCN genes using joint tissues obtained during total knee and hip joint replacement procedures on patients with advanced OA or RA. Normal joint tissues taken while performing bipolar hip replacement surgeries were used as controls. Results: All CCN genes were expressed at higher levels in OA and RA synovial samples as compared with normal controls. Whereas CCN3 and CCN6 were undetectable in control, OA, and RA cartilage, CCN1, CCN2, CCN4, and CCN5 were expressed to a greater extent in OA and RA knee cartilage. Conclusions: Our results indicate an involvement of several CCN genes in the pathophysiology of OA and RA. © 2015, The Japanese Orthopaedic Association.

Subject(s)

CCN protein
 CCN4 protein
 CCN5 protein
 CCN6 protein
 Connective tissue growth factor
 Cysteine rich protein 61
 Nephroblastoma overexpressed protein
 Protein
 Unclassified drug
 CCN protein
 Messenger RNA
 Aged
 Article
 Cartilage cell
 Clinical article
 Controlled study
 Female
 Gene expression
 Hip
 Hip arthroplasty
 Histology
 Human
 Human tissue
 In situ hybridization
 Knee
 Knee meniscus
 Male
 Osteoarthritis
 Pathophysiology
 Rheumatoid arthritis
 Synovium
 Very elderly
 Articular cartilage
 Biosynthesis
 Gene expression profiling
 Gene expression regulation
 Genetics
 Metabolism
 Osteoarthritis
 Polymerase chain reaction
 Procedures
 Rheumatoid arthritis
 Aged
 Aged, 80 and over
 Arthritis, Rheumatoid
 Cartilage, Articular
 CCN Intercellular Signaling Proteins
 Female
 Gene Expression Profiling
 Gene Expression Regulation
 Humans
 In Situ Hybridization
 Male
 Osteoarthritis
 Polymerase Chain Reaction
 RNA, Messenger
 Synovial Membrane

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URI

https://hdl.handle.net/20.500.14740/6121

Collections

Scopus: Year 1983-2021

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