Publication:
Serum zinc levels in thai children with acute diarrhoea

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Issued Date

2018

Resource Type

Article

File Type

application/pdf

ISSN

2249782X

DOI

10.7860/JCDR/2018/34703.11576

Other identifier(s)

2-s2.0-85047998517

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of Clinical and Diagnostic Research. Vol 12, No.6 (2018), p.SC01-SC04

Suggested Citation

Rerksuppaphol S., Na-Songkhla N., Rerksuppaphol L. Serum zinc levels in thai children with acute diarrhoea. Journal of Clinical and Diagnostic Research. Vol 12, No.6 (2018), p.SC01-SC04. doi:10.7860/JCDR/2018/34703.11576 Retrieved from: https://hdl.handle.net/20.500.14740/4164

Title

Serum zinc levels in thai children with acute diarrhoea

Author(s)

Rerksuppaphol S.
 Na-Songkhla N.
 Rerksuppaphol L.

Abstract

Introduction: Diarrhoea remains a leading cause of morbidity and mortality in children in developing countries. Zinc has been recommended by the WHO for the prophylaxis and treatment of acute diarrhoea. However, data on zinc levels in children remains scarce. Aim: To assess serum zinc levels in children admitted with acute diarrhoea to the paediatric unit of Srinakharinwirot University Hospital, Thailand. Materials and Methods: A cross-sectional study was conducted in children admitted to hospital with the diagnosis of acute diarrhoea, between July 2016 and February 2017. Children< 60 months, with watery and/or mucous stool >3 times within previous 24 hours were included. Anthropometric parameters were recorded. Serum electrolytes, Complete Blood Count (CBC) and serum zinc levels were measured. Children with serum zinc level lower than thresholds as recommended by the International Zinc Nutrition Consultation Group criteria and time of collection were defined as zinc deficient. The results were descriptively presented as mean and standard deviation, median and Interquartile Range (IQR), or frequency and percentage. Pearson’s chi-square or Fisher-exact test was used to compare proportions between groups, whereas, Student’s t-test or Mann-Whitney U-test was used to verify the differences of continuous variables. Results: Fifty children with acute diarrhoea were included in the study (50% female). The median duration of diarrhoea prior to admission was 24.0 hours (IQR, 12.0-72.0 hours) and the frequency of diarrhoeal episodes in preceding 24 hours was 4 times (IQR, 3-6 times). Mean serum zinc concentration at admission was 69.2±18.5μg/dL. A total of 22 (44%) children had zinc deficiency. There were no significant differences in demographic and clinical characteristics between patients with normal zinc levels and those with zinc deficiency. Conclusion: There is a high prevalence of low zinc levels in Thai children with acute diarrhoea. More efforts are needed towards improved coverage of zinc supplementation. © 2018, Journal of Clinical and Diagnostic Research. All rights reserved.

Subject(s)

Bicarbonate
 Chloride
 Creatinine
 Electrolyte
 Potassium
 Sodium
 Zinc
 Abdominal pain
 Acute diarrhea
 Anthropometry
 Article
 Blood cell count
 Body mass
 Child
 Clinical article
 Clinical assessment
 Coughing
 Cross-sectional study
 Dehydration
 Feces analysis
 Feces culture
 Female
 Fever
 Flame atomic absorption spectrometry
 Headache
 Hospitalization
 Human
 Immunoaffinity chromatography
 Infant
 Leukocyte count
 Male
 Mineral supplementation
 Platelet count
 Preschool child
 Prevalence
 Sore throat
 Urea nitrogen blood level
 Urinalysis
 Vomiting
 Zinc deficiency

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URI

https://hdl.handle.net/20.500.14740/4164

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Scopus: Year 1983-2021

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