Publication:
Surface modification of poly(D,L-lactic-co-glycolic acid) nanoparticles using sodium carboxymethyl cellulose as colloidal stabilizer

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Issued Date

2016

Resource Type

Article

File Type

application/pdf

ISSN

15672018

DOI

10.2174/1567201812666150904144241

Other identifier(s)

2-s2.0-84964076400

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Current Drug Delivery. Vol 13, No.1 (2016), p.95-104

Suggested Citation

Chittasupho C., Thongnopkoon T., Kewsuwan P. Surface modification of poly(D,L-lactic-co-glycolic acid) nanoparticles using sodium carboxymethyl cellulose as colloidal stabilizer. Current Drug Delivery. Vol 13, No.1 (2016), p.95-104. doi:10.2174/1567201812666150904144241 Retrieved from: https://hdl.handle.net/20.500.14740/5694

Title

Surface modification of poly(D,L-lactic-co-glycolic acid) nanoparticles using sodium carboxymethyl cellulose as colloidal stabilizer

Author(s)

Chittasupho C.
 Thongnopkoon T.
 Kewsuwan P.

Abstract

Poly(D,L-lactic-co-glycolic acid) nanoparticles (PLGA NPs) have been widely used as drug delivery systems for both small molecules and macromolecules. However, the colloidal stability problem remains unsolved. This study aims to investigate the possibility of using sodium carboxymethyl cellulose (SCMC) as a stabilizing agent of PLGA NPs. In this study, PLGA NPs were fabricated using various concentrations of SCMC (0.01, 0.1 and 0.5% w/v) by solvent displacement method. SCMC coated NPs were characterized using DLS, FTIR, DSC, colorimetric method. Particle size, polydispersity index, zeta potential values and SCMC adsorption increased with SCMC concentration. FTIR spectra, DSC thermograms and results of colorimetry suggested the interaction of SCMC and PLGA NPs. The stability of SCMC coated PLGA NPs was observed during the storage of three weeks in water. The stability of SCMC coated NPs in serum was also evaluated. Cell viability study revealed that there was no toxicity increased when SCMC was used as a stabilizing agent up to a concentration of 0.1% w/v. SCMC coated PLGA NPs bound A549 cells in a time dependent manner and with a greater extent than uncoated PLGA NPs. In conclusion, SCMC can be used to stabilize PLGA NPs by adsorbing on the surface of NPs. © 2016 Bentham Science Publishers.

Subject(s)

Carboxymethylcellulose
 Doxorubicin
 Nanoparticle
 Polyglactin
 Stabilizing agent
 Carboxymethylcellulose
 Drug carrier
 Excipient
 Lactic acid
 Nanoparticle
 Polyglycolic acid
 Polylactic acid-polyglycolic acid copolymer
 Adsorption
 Article
 Cell viability
 Colloid
 Colorimetry
 Controlled study
 Differential scanning calorimetry
 Dispersion
 Human
 Human cell
 Infrared spectroscopy
 Particle size
 Priority journal
 Surface property
 Zeta potential
 A-549 cell line
 Cell survival
 Chemistry
 Drug delivery system
 Drug effects
 Drug stability
 Procedures
 Tumor cell line
 A549 Cells
 Adsorption
 Carboxymethylcellulose Sodium
 Cell Line, Tumor
 Cell Survival
 Drug Carriers
 Drug Delivery Systems
 Drug Stability
 Excipients
 Humans
 Lactic Acid
 Nanoparticles
 Particle Size
 Polyglycolic Acid

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URI

https://hdl.handle.net/20.500.14740/5694

Collections

Scopus: Year 1983-2021

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