Publication:
A microfluidic paper-based analytical device for rapid quantification of particulate chromium

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Issued Date

2013

Resource Type

Article

File Type

application/pdf

ISSN

32670

DOI

10.1016/j.aca.2013.09.008

Other identifier(s)

2-s2.0-84885224611

Rights Holder(s)

Scopus

Bibliographic Citation

Analytica Chimica Acta. Vol 800, No. (2013), p.50-55

Suggested Citation

Rattanarat P., Dungchai W., Cate D.M., Siangproh W., Volckens J., Chailapakul O., Henry C.S. A microfluidic paper-based analytical device for rapid quantification of particulate chromium. Analytica Chimica Acta. Vol 800, No. (2013), p.50-55. doi:10.1016/j.aca.2013.09.008 Retrieved from: https://hdl.handle.net/20.500.14740/6531

Title

A microfluidic paper-based analytical device for rapid quantification of particulate chromium

Author(s)

Rattanarat P.
 Dungchai W.
 Cate D.M.
 Siangproh W.
 Volckens J.
 Chailapakul O.
 Henry C.S.

Abstract

Occupational exposure to Cr is concerning because of its myriad of health effects. Assessing chromium exposure is also cost and resource intensive because the analysis typically uses sophisticated instrumental techniques like inductively coupled plasma-mass spectrometry (ICP-MS). Here, we report a novel, simple, inexpensive microfluidic paper-based analytical device (μPAD) for measuring total Cr in airborne particulate matter. In the μPAD, tetravalent cerium (Ce(IV)) was used in a pretreatment zone to oxidize all soluble Cr to Cr(VI). After elution to the detection zone, Cr(VI) reacts with 1,5-diphenylcarbazide (1,5-DPC) forming 1,5-diphenylcarbazone (DPCO) and Cr(III). The resulting Cr(III) forms a distinct purple colored complex with the DPCO. As proof-of-principle, particulate matter (PM) collected on a sample filter was analyzed with the μPAD to quantify the mass of total Cr. A log-linear working range (0.23-3.75μg; r2=0.998) between Cr and color intensity was obtained with a detection limit of 0.12μg. For validation, a certified reference containing multiple competing metals was analyzed. Quantitative agreement was obtained between known Cr levels in the sample and the Cr measured using the μPAD. © 2013 Elsevier B.V.

Subject(s)

1 ,5-diphenylcarbazide
 Airborne particulate matters
 Instrumental techniques
 Occupational exposure
 Paper-based analytical devices
 Particulate Matter
 Proof of principles
 Quantitative agreement
 Analytic equipment
 Chromium
 Chromium compounds
 Inductively coupled plasma
 Inductively coupled plasma mass spectrometry
 Microfluidics
 1,5 diphenylcarbazone
 Carboxyl group
 Cerium
 Chromium
 Diphenylcarbazide
 Tetravalent cerium
 Unclassified drug
 Accuracy
 Article
 Chemical analysis
 Chemical parameters
 Color intensity
 Colorimetry
 Complex formation
 Concentration (parameters)
 Controlled study
 Elution
 Filter
 General device
 Limit of detection
 Microfluidic analysis
 Molecular weight
 Paper based analytical device
 Particulate matter
 Priority journal
 Product development
 Quantitative analysis
 Reaction time
 Reproducibility
 Shelf life
 Temperature sensitivity
 Validation process
 Chromium
 Microfluidics
 Paper-based analytical device
 Particulate matter
 Cerium
 Chromium
 Colorimetry
 Diphenylcarbazide
 Hydrogen-Ion Concentration
 Microfluidic Analytical Techniques
 Microwaves
 Nitric Acid
 Oxidation-Reduction
 Paper
 Particulate Matter
 Polyethylenes
 Quaternary Ammonium Compounds

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URI

https://hdl.handle.net/20.500.14740/6531

Collections

Scopus: Year 1983-2021

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