Publication:
Investigation on biological activities of anthranilic acid sulfonamide analogs

1
0

Issued Date

2011

Resource Type

Article

File Type

application/pdf

ISSN

16112156

Other identifier(s)

2-s2.0-84855815989

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

EXCLI Journal. Vol 10, (2011), p.155-161

Suggested Citation

Doungsoongnuen S., Worachartcheewan A., Pingaew R., Suksrichavalit T., Prachayasittikul S., Ruchirawat S., Prachayasittikul V. Investigation on biological activities of anthranilic acid sulfonamide analogs. EXCLI Journal. Vol 10, (2011), p.155-161. Retrieved from: https://hdl.handle.net/20.500.14740/7198

Title

Investigation on biological activities of anthranilic acid sulfonamide analogs

Author(s)

Doungsoongnuen S.
 Worachartcheewan A.
 Pingaew R.
 Suksrichavalit T.
 Prachayasittikul S.
 Ruchirawat S.
 Prachayasittikul V.

Abstract

In the previous studies, the cytotoxicities of anthranilate sulfonamides were investigated. Herein, the bioactivities of 4-substituted (X = NO2, OCH3, CH3, Cl) benzenesulfonamides of anthranilic acid (5-8) are reported. The results revealed that all sulfonamides selectively exerted antifungal activity (25-50% inhibition) against C. albicans at 4 μg/mL. Furthermore, compounds 6 and 8 show antioxidative (SOD) activity. These sulfonamides, except for 6, selectively display cytotoxic effects toward MOLT-3 cells. It is interesting to note that sulfonamides with electron withdrawing substituent (5, X = NO2) exhibited the highest cytotoxicity. This study provided preliminary structure-activity relationship of the anthranilic sulfonamides that is useful for further in-depth investigation.

Subject(s)

2 (4' chlorophenylsulfonamido)benzoic acid
 2 (4' methoxyphenylsulfonamido)benzoic acid
 2 (4' methylphenylsulfonamido)benzoic acid
 2 (4' nitrophenylsulfonamido)benzoic acid
 Ampicillin
 Antifungal agent
 Antiinfective agent
 Antioxidant
 Benzenesulfonamide derivative
 Cytotoxic agent
 Doxorubicin
 Etoposide
 Unclassified drug
 Antifungal activity
 Antioxidant activity
 Article
 Candida albicans
 Concentration response
 Controlled study
 Cytotoxicity
 Drug mechanism
 Drug structure
 Human
 Human cell
 Minimum inhibitory concentration
 Nonhuman
 Structure activity relation

View online Resources

Research Projects

Organizational Units

Journal Issue

URI

https://hdl.handle.net/20.500.14740/7198

Collections

Scopus: Year 1983-2021

Endorsement

Review

Supplemented By

Referenced By