Publication:
Antibacterial Pterocarpans from Erythrina subumbrans

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Issued Date

2007

Resource Type

Article

File Type

application/pdf

ISSN

3788741

DOI

10.1016/j.jep.2006.09.022

Other identifier(s)

2-s2.0-33846787105

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Journal of Ethnopharmacology. Vol 110, No.1 (2007), p.171-175

Suggested Citation

Rukachaisirikul T., Innok P., Aroonrerk N., Boonamnuaylap W., Limrangsun S., Boonyon C., Woonjina U., Suksamrarn A. Antibacterial Pterocarpans from Erythrina subumbrans. Journal of Ethnopharmacology. Vol 110, No.1 (2007), p.171-175. doi:10.1016/j.jep.2006.09.022 Retrieved from: https://hdl.handle.net/20.500.14740/4783

Title

Antibacterial Pterocarpans from Erythrina subumbrans

Author(s)

Rukachaisirikul T.
 Innok P.
 Aroonrerk N.
 Boonamnuaylap W.
 Limrangsun S.
 Boonyon C.
 Woonjina U.
 Suksamrarn A.

Abstract

Seven pterocarpans, erybraedin B (1), erybraedin A (2), phaseollin (3), erythrabyssin II (4), erystagallin A (5), erythrabissin-1 (6) and erycristagallin (7), two flavanones, 5-hydroxysophoranone (8) and glabrol (9), and one isoflavone, erysubin F (10), were isolated from the stems of Erythrina subumbrans (Leguminosae). Their structures were identified by means of spectroscopy. This is the first report of the isolation of the non-alkaloidal compounds from Erythrina subumbrans and the observed dehydration of 6a-hydroxypterocarpans 5 and 6 in CDCl3 to the corresponding pterocarpenes 11 and 12, respectively. Compounds 8 and 9 were isolated for the first time from the genus Erythrina. Compounds 2 and 4 exhibited the highest degree of activity against Streptococcus strains with an MIC range of 0.78-1.56 μg/ml, whereas compound 7 exhibited the highest degree of activity against Staphylococcus strains, including drug-resistant strains (MRSA and VRSA), with an MIC range of 0.39-1.56 μg/ml. Interestingly, compounds 2, 4, 5 and 7 were more active against several strains of Streptococcus and Staphylococcus than the standard antibiotics vancomycin and oxacillin. Compound 7 showed the highest level of activity against all VRSA strains tested, with an MIC range of 0.39-1.56 μg/ml, which were resistant to both antibiotics. These compounds may prove to be potent phytochemical agents for antibacterial activity, especially against the MRSA and VRSA strains. © 2006 Elsevier Ireland Ltd. All rights reserved.

Subject(s)

5 hydroxysophoranone
 Erybraedin a
 Erycristagallin
 Erystagallin a
 Erysubin f
 Erythrabissin 1
 Erythrabyssin ii
 Flavanone derivative
 Glabrol
 Isoflavone
 Oxacillin
 Phaseolin
 Pterocarpan derivative
 Unclassified drug
 Vancomycin
 Antibacterial activity
 Article
 Drug isolation
 Drug structure
 Erythrina
 Erythrina subumbrans
 Methicillin resistant Staphylococcus aureus
 Minimum inhibitory concentration
 Nonhuman
 Plant stem
 Staphylococcus
 Streptococcus
 Anti-Bacterial Agents
 Drug Resistance, Bacterial
 Erythrina
 Flavones
 Isoflavones
 Microbial Sensitivity Tests
 Molecular Structure
 Pterocarpans
 Staphylococcus
 Erythrina (angiosperm)
 Erythrina subumbrans
 Fabaceae
 Methicillin resistant Staphylococcus aureus
 Staphylococcus
 Streptococcus

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URI

https://hdl.handle.net/20.500.14740/4783

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Scopus: Year 1983-2021

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