Publication: Topical antifungal agents for seborrheic dermatitis: Systematic review and meta-analysis
3
0
Issued Date
2011
Resource Type
File Type
application/pdf
ISSN
1252208
Other identifier(s)
2-s2.0-79957687368
Rights Holder(s)
Scopus
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol 94, No.6 (2011), p.756-760
Suggested Citation
Apasrawirote W., Udompataikul M., Rattanamongkolgul S. Topical antifungal agents for seborrheic dermatitis: Systematic review and meta-analysis. Journal of the Medical Association of Thailand. Vol 94, No.6 (2011), p.756-760. Retrieved from: https://hdl.handle.net/20.500.14740/7317
Abstract
Objective: Assess the efficacy of topical antifungal agents for seborrheic dermatitis treatment. Material and Method: A systematic review and meta-analysis of all relevant randomized vehicle-controlled trials of topical antifungal agents for seborrheic dermatitis treatment were searched. The quality of the enrolled studies was measured by criteria from Cochrane Collaboration, followed by data extraction. Two reviewers independently assessed the present study articles. When there was a disagreement between the two reviewers, a consensus was made by the third reviewer. Pooled relative risk (PRR) statistical analysis was used to determine the efficacy of treatment. Results: One thousand ninety five studies were reviewed and nine studies were included. Four reports studied the efficacy of ketoconazole, two of metronidazole, two of ciclopirox, and one of bifonazole. Ketoconazole was more effective than vehicle [PRR is 5.78 (95% CI, 2.17-15.40)], as was metronidazole [PRR is 1.83 (95% CI: 1.05-3.17)] ciclopirox [PRR is 3.00 (95% CI, 1.86-4.84)], and bifonazole [PRR is 1.86 (95% CI: 0.96-3.59)]. Conclusion: The meta-analysis in the present study showed that the topical antifungal agents that demonstrated strong and moderate evidence of the efficacy for seborrheic dermatitis treatment were ketoconazole and ciclopirox, respectively. They could be used as an alternative treatment for seborrheic dermatitis.
Subject(s)
Antifungal agent
Bifonazole
Ciclopirox
Ketoconazole
Metronidazole
Adolescent
Aged
Controlled study
Data extraction
Drug efficacy
Evidence based medicine
Human
Information retrieval
Meta analysis
Quality control
Review
Risk factor
Seborrheic dermatitis
Systematic review
Administration, Cutaneous
Antifungal Agents
Dermatitis, Seborrheic
Gels
Humans
Randomized Controlled Trials as Topic
Treatment Outcome
Bifonazole
Ciclopirox
Ketoconazole
Metronidazole
Adolescent
Aged
Controlled study
Data extraction
Drug efficacy
Evidence based medicine
Human
Information retrieval
Meta analysis
Quality control
Review
Risk factor
Seborrheic dermatitis
Systematic review
Administration, Cutaneous
Antifungal Agents
Dermatitis, Seborrheic
Gels
Humans
Randomized Controlled Trials as Topic
Treatment Outcome