Publication:
Effect of zinc plus multivitamin supplementation on growth in school children

0
0

Issued Date

2016

Resource Type

Article

File Type

application/pdf

ISSN

13288067

DOI

10.1111/ped.13011

Other identifier(s)

2-s2.0-84994378051

Rights Holder(s)

Scopus

Bibliographic Citation

Pediatrics International. Vol 58, No.11 (2016), p.1193-1199

Suggested Citation

Rerksuppaphol S., Rerksuppaphol L. Effect of zinc plus multivitamin supplementation on growth in school children. Pediatrics International. Vol 58, No.11 (2016), p.1193-1199. doi:10.1111/ped.13011 Retrieved from: https://hdl.handle.net/20.500.14740/5018

Title

Effect of zinc plus multivitamin supplementation on growth in school children

Author(s)

Rerksuppaphol S.
 Rerksuppaphol L.

Abstract

Background: Zinc and multiple vitamins are essential for growth. Zinc and vitamin deficiency is very common in developing countries. The aim of this study was to assess the efficacy of zinc plus multivitamin supplements in improving growth of healthy Thai schoolchildren. Methods: A randomized controlled trial was conducted in healthy 4–13-year-old Thai schoolchildren attending public school in central Thailand. Participants were randomized to receive either chelated zinc in the form of zinc bis-glycinate (20 mg elemental zinc) plus multivitamins (vitamin A, 1000 IU; vitamin D, 200 IU; B1, 10 mg; B2, 3 mg; B6, 1 mg; B12, 10 μg; nicotinamide, 40 mg) or placebo once per day, 5 days per week for 6 months. Primary outcome was change in height from baseline to the end of the study. Secondary outcomes were change in weight, body mass index, waist and hip circumferences and waist-to-height ratio. An intention-to-treat analysis was performed. Results: Seventy children each were randomized to the treatment and placebo groups. The children who received zinc and multivitamins had significantly higher gain in height (4.9 ± 1.3 vs 3.6 ± 0.9 cm, respectively; P < 0.001). Subgroup analysis showed significant improvement in height, especially in preadolescents. The increased gain in height was irrespective of baseline height and weight. The extra gain in height occurred after 2 months of supplementation. The changes in other anthropometric indices were not significantly different. Conclusion: Supplementation of chelated zinc plus multivitamins for 6 months significantly increased height gain in Thai schoolchildren and was well tolerated. © 2016 Japan Pediatric Society

Subject(s)

Cyanocobalamin
 Nicotinamide
 Pyridoxine
 Retinol
 Riboflavin
 Thiamine
 Unclassified drug
 Vitamin D
 Zinc bis glycinate
 Zinc derivative
 Vitamin
 Zinc
 Article
 Body height
 Body weight
 Child
 Child growth
 Child parent relation
 Controlled study
 Diet supplementation
 Female
 Hip circumference
 Human
 Informed consent
 Male
 Normal human
 Outcome assessment
 Priority journal
 Randomized controlled trial
 Thailand
 Waist circumference
 Waist to height ratio
 Adolescent
 Child development
 Dietary supplement
 Dose response
 Drug effects
 Preschool child
 Reference value
 School
 Single blind procedure
 Adolescent
 Body Height
 Body Weight
 Child
 Child Development
 Child, Preschool
 Dietary Supplements
 Dose-Response Relationship, Drug
 Female
 Humans
 Male
 Reference Values
 Schools
 Single-Blind Method
 Thailand
 Vitamins
 Zinc

View online Resources

Research Projects

Organizational Units

Journal Issue

URI

https://hdl.handle.net/20.500.14740/5018

Collections

Scopus: Year 1983-2021

Endorsement

Review

Supplemented By

Referenced By