Publication:
Relationship of opioid receptors with GABAergic neurons in the rat inferior colliculus

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Issued Date

2006

Resource Type

Article

File Type

application/pdf

ISSN

0953816X

DOI

10.1111/j.1460-9568.2006.05098.x

Other identifier(s)

2-s2.0-33750046614

Rights Holder(s)

Scopus

Bibliographic Citation

European Journal of Neuroscience. Vol 24, No.7 (2006), p.1987-1994

Suggested Citation

Tongjaroenbuangam W., Jongkamonwiwat N., Phansuwan-Pujito P., Casalotti S.O., Forge A., Dodson H., Govitrapong P. Relationship of opioid receptors with GABAergic neurons in the rat inferior colliculus. European Journal of Neuroscience. Vol 24, No.7 (2006), p.1987-1994. doi:10.1111/j.1460-9568.2006.05098.x Retrieved from: https://hdl.handle.net/20.500.14740/5467

Title

Relationship of opioid receptors with GABAergic neurons in the rat inferior colliculus

Author(s)

Tongjaroenbuangam W.
 Jongkamonwiwat N.
 Phansuwan-Pujito P.
 Casalotti S.O.
 Forge A.
 Dodson H.
 Govitrapong P.

Abstract

The inferior colliculus is a critical structure for processing auditory information and receives ascending and descending synaptic auditory projections. In addition to GABAergic and glutamatergic innervations, other neurotransmitter systems are also reported in the inferior colliculus, including opioid peptides. In the present study, the relative distribution of each type of opioid receptor, mu (MOR), delta (DOR) and kappa (KOR) within GABAergic neurons in the inferior colliculus was examined. GABA immunoreactivity was expressed by small, medium and large neurons and distributed in the central nucleus and the pericentral nucleus of the inferior colliculus. Immunostaining for MOR, DOR and KOR receptors was found in both disc-shaped cells and stellate cells. Punctiform β-endorphin immunolabelling was observed in the proximity of GABA-positive neurons. Co-localization of GABA and MOR receptors was observed in neurons and nerve terminals in the central nucleus, dorsal cortex and external cortex of the inferior colliculus. Quantification of the co-localization patterns determined that a higher proportion of GABA neurons was associated with MOR receptors compared with KOR or DOR receptors. © The Authors (2006).

Subject(s)

4 aminobutyric acid receptor
 Beta endorphin
 Delta opiate receptor
 Kappa opiate receptor
 Mu opiate receptor
 Opiate receptor
 Animal cell
 Animal experiment
 Animal model
 Animal tissue
 Antibody labeling
 Article
 Controlled study
 GABAergic transmission
 Immunohistochemistry
 Immunoreactivity
 Inferior colliculus
 Male
 Nerve ending
 Nonhuman
 Olfactory receptor
 Priority journal
 Protein localization
 Quantitative analysis
 Rat
 Receptor binding
 Receptor density
 Synaptic transmission
 Tissue distribution
 Animals
 Beta-Endorphin
 Blotting, Northern
 Cell Count
 Fluorescent Antibody Technique
 Gamma-Aminobutyric Acid
 Gene Expression
 Inferior Colliculi
 Inferior Colliculus
 Male
 Neurons
 Rats
 Rats, Sprague-Dawley
 Receptors, Opioid
 Reverse Transcriptase Polymerase Chain Reaction
 RNA, Messenger

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URI

https://hdl.handle.net/20.500.14740/5467

Collections

Scopus: Year 1983-2021

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