Publication: Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis
1
0
Issued Date
2018
Resource Type
File Type
application/pdf
ISSN
23146133
Other identifier(s)
2-s2.0-85057390706
Rights Holder(s)
Scopus
Bibliographic Citation
BioMed Research International. Vol 2018, (2018)
Suggested Citation
Angkananard T., Anothaisintawee T., Mcevoy M., Attia J., Thakkinstian A. Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis. BioMed Research International. Vol 2018, (2018). doi:10.1155/2018/2703518 Retrieved from: https://hdl.handle.net/20.500.14740/3966
Abstract
Objective. This systematic review aimed to measure the association between neutrophil lymphocyte ratio (NLR) and cardiovascular disease (CVD) risk. Methods. Relevant studies were identified from Medline and Scopus databases. Observational studies with NLR as a study factor were eligible for review. The outcomes of interest were any type of CVD including acute coronary syndrome, coronary artery disease, stroke, or a composite of these cardiovascular events. Mean differences in NLR between CVD and non-CVD patients were pooled using unstandardized mean difference (USMD). Odds ratios of CVD between high and low NLR groups were pooled using a random effects model. Results. Thirty-eight studies (n=76,002) were included. High NLR was significantly associated with the risks of CAD, ACS, stroke, and composite cardiovascular events with pooled ORs of 1.62 (95% CI: 1.38-1.91), 1.64 (95% CI: 1.30, 2.05), 2.36 (95% CI: 1.44, 2.89), and 3.86 (95% CI: 1.73, 8.64), respectively. In addition, mean NLRs in CAD, ACS, and stroke patients were significantly higher than in control groups. Conclusion. High NLR was associated with CAD, ACS, stroke, and composite cardiovascular events. Therefore, NLR may be a useful CVD biomarker. © 2018 Teeranan Angkananard et al.
Subject(s)
Acute coronary syndrome
Cardiovascular disease
Cardiovascular risk
Cerebrovascular accident
Clinical outcome
Coronary artery disease
Disease association
Human
Medline
Neutrophil lymphocyte ratio
Review
Scopus
Systematic review
Cardiovascular disease
Immunology
Lymphocyte
Meta analysis
Neutrophil
Odds ratio
Pathology
Publishing
Risk factor
Treatment outcome
Cardiovascular Diseases
Humans
Lymphocytes
Neutrophils
Odds Ratio
Publication Bias
Risk Factors
Treatment Outcome
Cardiovascular disease
Cardiovascular risk
Cerebrovascular accident
Clinical outcome
Coronary artery disease
Disease association
Human
Medline
Neutrophil lymphocyte ratio
Review
Scopus
Systematic review
Cardiovascular disease
Immunology
Lymphocyte
Meta analysis
Neutrophil
Odds ratio
Pathology
Publishing
Risk factor
Treatment outcome
Cardiovascular Diseases
Humans
Lymphocytes
Neutrophils
Odds Ratio
Publication Bias
Risk Factors
Treatment Outcome